Radiosurgery recurrence

Lederman G, Arbit E, Odaimi M, Lombardi E, Wrzolek M, Wronski M. Fractionated stereotactic radiosurgery and concurrent taxol in recurrent glioblastoma multiforme a preliminary report. Int J Radiat Oncol Biol Phys 1998 40(3) 661-666. 

Current treatment strategies for GBM are multimodal and typically involve surgical resection followed by radiation therapy and chemotherapy. Upon tumor recurrence repeat resection or stereotactic radiosurgery followed by additional... 

Chernov M, Hayashi M, Izawa M, Ochiai T, Usukura M, Abe K, Orio Y, Muragaki Y, Kubo O, Hori T, Takakura K (2005) Differenda-dori of die radiadon-induced necrosis and tumor recurrence after gamma knife radiosurgery for brain metastases Importance of muld-voxel proton MRS. Minim Invasive Neurosurg 48 228—234. 

AVM location hemispheric location of the AVM was correlated to better OR (Pollock et al. 1998). There is more risk of clinical complications with radiosurgery of brain-stem AVMs than of superficial AVMs (Karlsson et al. 1996). A recent series reported the results in 45 patients with brain-stem AVMs (Regis et al. 2001). The overall OR was 82%. Complications were neurological deficit in three patients (two permanent) and recurrent hemorrhage in two. Choroidal and cisternal AVMs seem to be less radiosensitive, with an OR of 47.6% (Nataf et al. 2001d). 

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