Radiokinetics in rats

Blood/plasma (from exsanguination, see study blood/plasma radiokinetics in rat )... [Pg.581]

The study is performed separately from the radiokinetics blood/plasma study in rats not to influence the results by collecting blood during the study course. [Pg.568]

As examples in the following chapter, the frequently used radiokinetic studies in dogs and rats are described, including placental transfer and milk... [Pg.559]

The estimation of absorption based on the urine excretion ratio (oral/intravenous) should be compared with the ratio of dose-normalized plasma AUCs after iv. and oral administration from the rat radiokinetic study. In case of major differences between both methods of absorption determination, a thorough investigation/discussion of a route of administration-dependent metabolism and/or volume of distribution might help to explain the apparent discrepancy. [Pg.571]

HMR 1766 is a guanylat-cyclase activator and is being developed for treatment of hypertension. It was 14C-labeled and investigated in a rat radiokinetic study to determine the time course of radioactivity concentrations in blood and plasma. [Pg.576]

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