Radio-iodination reactions

Fig. 17. Chloramine-T (left) and Iodo-gen (right) reagents, used in radio-iodination reactions.

A sample of iodine-128 was produced in a Szilard-Chalmers reaction by irradiating a sample of ethyl iodide in a neutron source. The radio-iodine was extracted with sodium thiosulfate solution and then counted in a Geiger counter at various time Intervals. Use the tabulated data of t in minutes against C counts/min to find the rate equation and the half time. 

Several of the alpha-ethyl analogues of ARIADNE were N,N-dialky lated, and were target compounds for halogenation with radio-iodine or radio-fluorine, for evaluation as potential brain blood-flow indicators. In these studies, all examples followed a common flow diagram. The reaction of the appropriate benzaldehyde... 

In paper electrophoresis, the I-DOTATATE conjugate was retained at the point of application and the free L moved towards the anode. The radio-iodination yield obtained was approximately 90%. The paper electrophoresis pattern of the reaction mixture of I-DOTATATE is shown in Fig. 8.10. With SepPak separation, free L was eluted in the phosphate buffer, while the conjugate was obtained in pure form in the ethanol fraction. 

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