Radical Reactions Mediated by Grignard Reagents

Since the Grignard reagent was discovered in 1900 it has been widely used for fhe construction of organic molecules. It is the most basic and indispensable tool for organic chemists [150, 151]. There have been reports of radical reactions using Grignard reagents in the presence or absence of transition metal catalysts [152]. Synthetic applications of this type of reaction have, however, been quite limited so far. 

It is probable that in some forced reactions dissociation of the Grignard reagent in the sense (R-MgX R -i- eMgX) occurs, but in general no equilibrium is achieved in such reactions, because of the reactivity of the radicals R toward each other or toward other components of the reaction system. 

---

Radical Reaction Mediated by Grignard Reagents in the Presence... 

In 1998, Oshima and coworkers ° reported few examples of radical cyclization mediated by Grignard reagents in the presence of iron(II) chloride (Scheme 57). However, this reaction often gives moderate yields. 

---