Rabeprazole Theophylline

Humphries TJ, Naidi RV, Spera AC, T.a7ar JD, Laurent AL, Spanyers SA Coadministiation of rabeprazole sodium (E3810) does not affect the pharmacokinetics of anhydrous theophylline O warfarin Gostioewteratogy (1996) 110 (Siqpl), A138. 

Omeprazole may cause a small increase in theophylline clearance, and lansoprazole may canse a small decrease in theophylline levels, neither of which are likely to be clinically relevant Pantopra-zole and rabeprazole do not appear to interact with theophylline. 

A single 250-mg oral dose of theophylline was given to 25 patients before and after taking rabeprazole 20 mg or a placebo daily for 7 days. No significant changes in the pharmacokinetics of theophylline were seen. 

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