Drug interaction, rabeprazole

Omeprazole (Prilosec) was the original PPI this drug is now joined by esomeprazole (Nexium), lansoprazole (Prevacid), pantoprazole (Protonix), and rabeprazole (AcipHex) (see Table 27-2). All of these drugs are similar, with selection often depending on cost, availability, and the drug interaction potential of each agent.15 Likewise, nonprescription forms of certain PPIs are now available, and these forms offer a convenient,... 

Drug interactions with omeprazole are of particular concern in patients who are considered slow metabolizers, as found in approximately 3% of the Caucasian population. Unfortunately, it is unclear which patients have the polymorphic gene variation that makes them slow metabolizers. Like omeprazole, the metabolism of esomeprazole may also be altered in patients with this polymorphic gene variation. Rabeprazole increases digoxin trough concentrations by approximately 20%. Patients on potentially interacting drugs should be monitored closely for potential problems. 

Humphries TJ,NardiRV, Lazar JD, Spanyers SA. Drug-drug interaction evaluation of rabeprazole sodium a clean/e qDected slate Gut (1996) 39 (Siq)pl 3), A47. 

Information on rabeprazole is still limited. Similar to the other PPIs, its potential to interact with other drugs and its ability to induce CYP lA isoenzymes seem to be low [65, 70]. 

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