Rab-GTPases

Leung KF, Baron R, Seabra MC (2006) Geranylgeranyla-tion of Rab GTPases. J Lipid Res 47 467-475... 

Chavrier, P. and Goud, B. The role of ARF and Rab GTPases in membrane transport. Curr. Opin. Cell Biol. 11 466-475, 1999. 

Pfeffer, S. R. Rab GTPases specifying and deciphering organelle identity and function. Trends Cell Biol. 11 487- 91, 2001. 

Segev, N. Ypt/rab gtpases regulators of protein trafficking. Sci. STKE2001 RE11,2001. 

Pan, X., Eathiraj, S., Munson, M., and Lambright, D. G. (2006). TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature 442, 303-306. 

Seachrist JL, Ferguson SSG. 2003. Regulation of G protein-coupled receptor endocytosis and trafficking by Rab gtpases. Life Sci 74 225-235. 

The Ras superfamily of small monomeric GTP-binding proteins consists of at least 13 small GTPases. We have already mentioned the enormous functional diversity of the monomeric G proteins, of which many aspects are still unclear (see Chapter 3). For example, the Rab GTPases regulate vesicular protein traffic and direct the transport vesicles to their targets in eukaryotic cells . Another monomeric G protein. Ran, regulates transport in and out of the nucleus. Moreover, Ran in the active, GTP-bound form... 

T. Lazar, M. Gotte, and D. Gallwitz. Vesicular transport how many Ypt/Rab-GTPases make a eukaryotic cell Trends Biochem Sci, 22, 468—472, 1997. 

Rab4 that make it apparently unique with regard to this particular combination of posttranslational modifications on Rab GTPases remain to be determined. 

Pfeffer, S.R., Dirac-Svejstrup, A.B., and Soldati, T. (1995). Rab GDP dissociation inhibitor putting Rab GTPases in the right placs. J Biol Chem 270 17057-17059. 

Leung, K.F., Baron, R., and Seabra, M.C. (2006). Thematic review series lipid posttranslational modifications geranylgeranylation of Rab GTPases. 7 Lipid Res 47 467-475. 

Brunsveld L, Watzke A, Durek T, Alexandrov K, Goody RS, Waldmann H. Synthesis of functionalized Rab GTPases by a combination of solution- or solid-phase hpopeptide synthesis with expressed protein hgation. Chemistry 2005 11 2756-2772. 

Pfeffer S, Aivazian D. Targeting RAB GTPases to distinct membrane compartments. Nat. Rev. Mol. Cell Biol. 2004 5 886-896. 

Brunsveld L, Watzke A, Durek T, Alexandrov K, Goody RS, Waldmann H. Synthesis of functionalized rab GTPases by a combination of solution- or solid-phase Upopeptide synthesis with expressed protein ligation. Chemistry 2005 11(9) 2756-2772. Rak A, Pylypenko O, Durek T, Watzke A, Kushnir S, Brunsveld L, et al. Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPTl GTPase. Science 2003 302(5645) 646-650. Paulus H. Protein splicing and related forms of protein autoprocessing. Annu. Rev. Biochem. 2000 69(1) 447-496. 

NOVKK PJ, BRENNWAID P. Friends and family the role of die rab GTPases in vesicular traffic. Cdl 75, 597-602,1993. 

Rab GTPases Control Docking of Vesicles on Target Membranes... 

Schimmdller, R, I. Simon, and S. Pfeffer. 1998. Rab GTPases, directors of vesicle docking. J. Biol. Chem. 273 22161-22164. 

In this way, membrane association of prenylated Rho- and Rab-GTPases is modulated by their cognate GDP dissociation inhibitor proteins (Y. An, 2003 A. Rak, 2003). 

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