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Quinoxaline ring fission

Chloro-1 -methyl-3-trifluoromethyl- //-[ 1,3,4]oxadiazmo[5,6-fc]quinoxaline (570) suffered thiolytic ring fission in refluxing pyridine (containing phosphorus penta-sulfide) during 1 h to provide 7-chloro-3-[7/-methyl-A( -(triiluoroacetyl)hydrazino]-2(17/)-quinoxalinethione (571) in 87% yield. ... [Pg.78]

Pyrazolo[3,4-/>]quinoxalines can undergo ring fission under reductive or hydrolytic conditions to give different types of quinoxalme. The following examples illustrate these possibilities. [Pg.79]

Note A few typical examples of the aromatization of alkylated or arylated hydroquinoxalines and of the oxidative ring fission of quinoxalines are given here. More mundane examples are given passing mention in other chapters. [Pg.126]

There is an extensive literature on the use of 2,1,3-benzoxadiazole 1-oxide [often called benzofuroxanie) (BFO) (462)] as a substrate for the primary synthesis of quinoxaline 1,4-dioxides and occasionally quinoxaline mono-A -oxides or even simple quinoxalines. Very few substituted derivatives of the parent substrate (462) have been employed in recent years. The general mechanism clearly involves a fission (usually amine-catalyzed) of the oxadiazole ring followed by reaction with an ancillary synthon. The following examples are divided according to the type of synthon employed. [Pg.62]


See other pages where Quinoxaline ring fission is mentioned: [Pg.8]    [Pg.8]    [Pg.537]   
See also in sourсe #XX -- [ Pg.354 , Pg.355 ]




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