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Quinone methide Redox reaction

Illustrated in Scheme 7.8 are the mechanisms that give rise to the products shown in Scheme 7.7. These mechanisms involve either electrophilic attack or an internal redox reaction. The internal redox reaction shown in Scheme 7.8 involves proton trapping from the solvent or from the hydroquinone hydroxyl group as shown. This process has been documented for the mitomycin system50 and also occurs in many quinone methide systems.25,30,31... [Pg.225]

Figure 7 Proposed mechanism for formation of free radicals and porential alkylating agents by anchracyclines in the presence of redox enzymes (flavc oteins IF]), which reduce die anihracy-dine in a one-electron step to the semiquinone. The Cj-quinone methide, a potential alkylating agent, is a tautomer of the deoxyaglycone produced from this reaction. (Redrawn and modified from Ref. 206.)... Figure 7 Proposed mechanism for formation of free radicals and porential alkylating agents by anchracyclines in the presence of redox enzymes (flavc oteins IF]), which reduce die anihracy-dine in a one-electron step to the semiquinone. The Cj-quinone methide, a potential alkylating agent, is a tautomer of the deoxyaglycone produced from this reaction. (Redrawn and modified from Ref. 206.)...
See other pages where Quinone methide Redox reaction is mentioned: [Pg.209]    [Pg.329]    [Pg.157]    [Pg.157]    [Pg.682]    [Pg.1192]    [Pg.47]    [Pg.271]   
See also in sourсe #XX -- [ Pg.621 ]



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