Quinolones prophylaxis

Engels EA, Lau J, Barza M. Efficacy of quinolone prophylaxis in neutropenic cancer patients A meta-analysis. J CUn Oncol 1998 16 1179-1187. 

Quinolones are NOT meant for children. A word of caution is necessary about prophylaxis do not begin prophylaxis too early. If it is begun during the incubation period, prophylaxis may delay but not prevent the onset of symptoms. As a result of this, doxycycline or tetracycline should be started eight to twelve days post exposure. This type of regimen has been shown to prevent clinical disease. 

Un, acute exacerbation of chronic bronchitis prophylaxis in transurethral procedures Action Quinolone antibiotic -1- DNA gyrase. Dose 400 mg/d PO X w/ renal insuff, avoid antacids Caution [C, —] Interactions w/ cation-containing products Contra Quinolone all gy, children <18 y,T QT interval, X Disp Tabs SE NA/ /D, abd pain, photosens, Szs, HA, dizziness, tendon rupture, periph al neuropathy, pseudomembranous cohtis, anaphylaxis Interactions t Effects W/ cimetidine, probenecid T effects OF cyclosporine, warfarin, caffeine X effects W/ antacids EMS Monitor ECG for TqT int val, esp in pts taking class lA/III antiarrhythmics monitor ECG and BP for signs of h5 povolemia and electrol5rte disturbances (hypokalemia) d/t D T risk of photosensitivity Rxns OD May cause NA /D, confusion and Szs symptomatic and supportive... 

Metliylbenzoquate is probably the most potent among the anticoccidial quinolone derivatives. It is often used at 8.35 ppm in the feed in conjunction with other coccidiostats, especially clopidol, for prophylaxis of coccidiosis in chickens and turkeys. 

Escherichia coli is a normal inhabitant of the bowel but some enterotoxigenic strains are pathogenic and are frequently a cause of travellers diarrhoea. A quinolone, e.g. ciprofloxacin, is the drug of choice in most high-risk parts of the world for a severe attack (see Travellers diarrhoea, p. 644). Antimicrobials are not generally given for prophylaxis but, when it is indicated, a quinolone should be used. 

The use of antibacterial prophylaxis remains controversial owing to a lack of consistent efficacy, potential for development of resistant bacteria, high cost, and lack of impact on patient survival. Therefore, antibacterial prophylaxis is not recommended routinely for all neutropenic patients. Prophylaxis (with trimethoprim-sulfamethoxazole or quinolone-penicillin) generally is indicated for patients expected to be profoundly neutropenic for more than 1 week, such as HSCT patients. Additional risk factors that may provide justification for prophylaxis include mucous membrane or skin lesions, presence of indwelling catheters, need for instrumentation, severe periodontal disease, or other risk factors. Neutrophil recovery eliminates the need for continued prophylaxis, and recovery may be facilitated by use of... 

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