Quinoline-5,8-quinones

C. Anthony, M. Ghosh, and C.C. Blake, The structure and function of methanol dehydrogenase and related quinoproteins containing pyrrolo-quinoline quinone. Biochem. J. 304, 665-674 (1994). [Pg.600]

Primaquine is the least toxic and most effective of the 8-aminoquinoline antimalarial compounds. The mechanism by which 8-aminoquinolines exert their antimalarial effects is thought to be through a quinoline-quinone metabolite that inhibits the coenzyme Q-mediated respiratory chain of the exoerythrocytic parasite. [Pg.614]

PYRROLO-QUINOLINE QUINONE (PQQ) THE PROSTHETIC GROUP OF METHANOL DEHYDROGENASE... [Pg.84]

The light-induced control of the electroactivity of charged redox-active substrates allows the functionalized electrode to be used to control electrochemical transformations. A system composed of two oppositely charged diffusional redox probes—positively charged 2,5-bis[[2-(dimethylbutylammo-nio)ethyl]amino]-l,4-benzoquinone (14) and negatively charged pyrrolo-quinoline quinone (PQQ) (15)—was used to demonstrate this behavior... [Pg.235]

Mechanism of action Primaquine forms quinoline-quinone metabolites, which are electron-transferring redox compounds that act as cellular oxidants. The drug is a tissue schizonticide and also limits malaria transmission by acting as a gametocide. [Pg.461]

The reaction of l-Boc-2-lithio-l,4-dihydropyridines with 3,4-disubstituted cyclobutadienes provides the quinoline quinone upon heating and treatment with acetic acid... [Pg.233]

Methoxantin coenzyme (PQQ, pyrrolo quinoline quinone, 2,7,9-tricarboxy-lff-pyrrolo-[2,3- /]-quinoline-4,5-dione, 4,5-dihydro-4,5-dioxo-lfl-pyrrolo[2,3 quinoline-2,7,9-tri-carboxylic acid) [72909-34-3] M... [Pg.884]

Quinone containing redox enzymes are a much less widely studied group, and to date fewer examples have been characterized. The prosthetic group in this case is a quinone, pyrrolo-quinoline quinone (PQQ), and again it is a two-electron... [Pg.238]

The electrochemistry of the PQQ (pyrrolo-quinoline quinone) prosthetic group has been investigated at poly(pyrrole)-coated electrodes, and PQQ has been entrapped within poly(pyrrole) films " good electrochemistry was observed in both cases. Poly(pyrrole) has also been used to entrap adenosine triphosphate (ATP) anions, again by growing the film in the presence of the anion, " and as an electrode material for oxidizing ascorbate. " In the latter case the oxidation... [Pg.262]

Quinaldine Quinoline Quinone Resorcinol Salicylic acid... [Pg.5133]

Pyrrolo quinoline quinone, PQQ 2,7,9-tricar-boxy-li/-pyrrolo [2,3-/ quinoline-4,5-dione, the cofactor of methanol dehydrogenase (EC 1.1.99.8) from Hyphomicrobium X and Melhylophilus methy-lotrophus, and of glucose dehydrogenase (EC 1.1.99.17) from Acinebacter cakoaceticus. [J. A. Duine et al. Eur. J.Biochem. 108 (1980) 187-192]... [Pg.580]

The Lewis acid and coordinating properties of trivalent lanthanides were used very early. In 1922, lanthanide trichlorides were compared to other metal halides as catalysts for acetalization (38). The first detailed study of the application of lanthanide derivatives to problems of organic synthesis seems to be the report of Pratt in 1962 (39) who showed that CeCl is a superior catalysts for the regioselective addition of p-toluidine on 5,8-quinoline-quinone (followed by reoxidation) (eq.j 26j). [Pg.61]

Green needles. Mp. 185°. Sol. EtOH. Spar, sol. EtgO, CgHg, CHCI3. FeCl3 —> quinoline quinone. [Pg.229]

Oxidations to Quinoline Quinones. Quinolinols are converted to quinoline quinones (eq 5). ... [Pg.489]

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