Quinoline methylation

Friedel-Crafts acylation, 2, 322 Quinoline, methyl-basicity, 2, 172 NMR, 2, 120 radical cations... 

Long-chain halides undergo this reaction at 100°, no C-dialkylated products being formed. In alkylations with aryl-substituted alkyl halides, Ar(CH,) X, n= 1 to 3, yields are improved by performing the reaction rapidly in liquid ammonia (56-9S>%). Also, quinoline methylated in the 2-or 4-position reacts in the same way. A methyl group in the 3-position of pyridine or quinoline is unreactive. 

Quinoline, dimethyl-(5 isomers) Quinoline, ethyl-(2 isomers) Quinoline, methyl-(6 isomers) Quinoline, (1-methylethyl)-... 

Quinoline, methyl-1,2,3,4-tetrahydro- several isomers present in MSS 1587 ... 

A number of azaarenes have also been detected in cigarette smoke (/7, 28, 56). These have included quinoline, methyl- and dimethylquinolines, isoquinoline, and alkylisoquinolines, benzo[/i]quinoline, acridine, phenan-thridine, benzo[/]quinoline, 4-azafluorenes, 1-azafluoranthenes, 4-azapyrenes, 9-methylcarbazoles, indole, alkylindoles, alkylcarbazoles, benzo[Z>]carbazole, dibenzo[c,g]carbazole, and benz[c]acridine. 

Thiazol 2-ones, 49-50, 62, 254 Thiazol-4- and -5-ones, 51-52 Thiazolo-[4,5-6]- and -[5,4-6]-quinolines, methylation of, 259 Thiocoumarin-3,4-diols, methylation of, 276... 

INaJninoi80iuootinic methyl ester 2.6- Dibeiizamidoisonicotiiuc methyl ester 2-Hydrazmo-6-chlorotsonioo-tinyl hydrazide 2,4T-Dihydroxy-6-hydrazino-nicotinyl hydrazide Quinolinic methyl ester Quinolinic anhydride -(106) — (106), 2,5-Dia-minoisoniootinyl hydrazide - (106) t - (119) t — (420) 0% (S6) 0% (106)... 

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