Quinoline, Isoquinoline, and Related Alkaloids

9 Quinoline, Isoquinoline, and Related Alkaloids 7.9.7 Characterization of Thiazinoquinoiinodione Alkaloids 

Copp and coworkers [78] reported the isolation of a pair of thiazine-containing quinolindione alkaloids from the New Zealand ascidian Aplidium sp. The HMBC spectrum optimized for 6 Hz afforded 

Grycova et al. [79] reviewed the Uterature of quaternary protoberberine alkaloids in early 2007. Although HMBC data were discussed in 

3 Covalent Bonding of Azoles to Quaternary Protoberberine Alkaloids 

In a 2008 study, Marek et al. [80] prepared various azole adducts of several protoberberine alkaloids that were studied by GSQMBC or 

Marek and coworkers have reported extensively on the utilization of direct and long-range 2D NMR methods isoquinoline, benzo[c]phenanthridine, and related 

Two other closely related benzyl isoquinoline alkaloids are papaverine (94) and escholamine iodide (95). The resonance of the fully aromatic isoquinoline of papaverine, as would be expected, was observed at 297.2 ppm. In contrast, the quaternary methyl iodide salt form of escholamine iodide shifted the resonance 

The investigation of bisbenzylisoquinolines has been an active area of natural product research that has been reviewed [112]. Frappier and coworkers [113] have studied and characterized some antiplasmodial bisbenzylisoquinoline alkaloids 

Orabi and coworkers [114] reported the elucidation ofthe structures of several bis-1 -oxaquinolizidine N-oxide alkaloids from Red Sea specimens of Xestospongia exigua, employing long-range HMBC data in the process. Two of the compounds 

The new quinoline alkaloid sarcomejine (100) was isolated from the bark of Sarcomdicope megistophyUa by Fokialakis et al. [115] The skeletal framework was assembled from NM R and mass spectrometric data, necessitating the authors to then differentiate between two alternative structures on the basis of a 5 Hz optimized long-range GHMBC spectrum. Correlations from the proton at the 8 position of 

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