Quinoline 2.3- dimethyl-4-phenyl

The name found its origin in the fact that the first dyes known were all derived from quinoline as, for example, 2,2 -cyanine (Scheme 1). In the case of an asymmetrical or symmetrical dye involving one or two nuclei that are different from the quinoline ring, the name of the nucleus becomes the prefix in the name of the dye. So 3.3 -dimethyl-4-phenyl thiazolo cyanine is the dye of structure 1 and 3.1 -dimethyl 4-phenyl thiazolo 2 -cyanine is represented by the formula structure 2 (Scheme 2). 

Abbreviations aapy, 2-acetamidopyridine Aik, alkyl AN, acetoniuile Ar, aryl Bu, butyl cod, 1,5-cyclooctadiene COE, cyclooctene COT, cyclooctatetraene Cp, cyclopentadienyl Cp , penta-methylcyclopentadienyl Cy, cyclohexyl DME, 1,2-dimethoxyethane DME, dimethylformamide DMSO, dimethyl sulfoxide dmpe, dimethylphosphinoethane dppe, diphenylphosphinoethane dppm, diphenylphosphinomethane dppp, diphenylphosphinopropane Et, ethyl Ec, feirocenyl ind, inda-zolyl Me, methyl Mes, mesitylene nb, norbomene orbicyclo[2.2.1]heptene nbd, 2,5-norbomadiene OTf, uiflate Ph, phenyl PPN, bis(triphenylphosphoranylidene)ammonium Pi , propyl py, pyridine pz, pyrazolate pz, substituted pyi azolate pz , 3,5-dimethylpyrazolate quin, quinolin-8-olate solv, solvent tfb, teti afluorobenzobaiTelene THE, tetrahydrofuran THT, tetrahydrothiophene tmeda, teti amethylethylenediamine Tol, tolyl Tp, HB(C3H3N2)3 Tp , HB(3,5-Me2C3HN2)3 Tp, substituted hydrotiis(pyrazol-l-yl)borate Ts, tosyl tz, 1,2,4-triazolate Vin, vinyl. 

As in the preceding subsection, l,2-bis(benzenesulfonylimino)-4,5-dimethyl-benzene (598) and 2-phenylthiazolo[3,2-fl]quinolinium-l-olate (599) in dichloromethane at 20°C during 15 min afforded l,4-bis(benzenesulfonyl)-6,7-dimethyl-3-phenyl-3-(quinolin-2-ylthio)-3,4-dihydro-2(l//)-quinoxalinone (600) in almost quantitative yield. " ... 

Benzo[f]quinazoline-l,3-diones, 55, 207 Benzo(/]quinazoline-1,3-dione, 2,4-dimethyl-6-phenyl-, 55, 226 Benzo[/i]quinazoline-2,4-diones, 55, 200 Benzo[g]quinoline-5,10-dione, 3-methyl-, 57, 14... 

A microwave-assisted three-component coupling reaction of 5-amino-3-phenyl-pyrazole, a cychc 1,3-dicarbonyl compound and an aromatic aldehyde has been described by Chebanov and co-workers [121]. Depending on the apphed reaction conditions a series of 4-aryl-3-phenyl-l,4,6,7,8,9-hexahydro-l// pyrazolo[3,4-h] quinolin-5-ones 80, 9-p-tolyl-6,6-dimethyl-2-phenyl 5,6,7,9-tetrahydro-pyrazolo [5,l-h]quinazolin-8-ones 81, or 4-aryl-5a-hydroxy-4,5,5a,6,7,8-hexahydropyra-zolo[4,3-c]quinolizin-9-ones 82 can be formed (Scheme 61). 

The synthesis as well as the structural and vibrational characterization of the HgL2Cl2 complex (L = 3,5-dimethyl-l-thiocarboxamide) have been reported <2005NJC833>. New metal chelates of Zn(ll) and Cd(n) (ML2) based on (4Z)-3-methyl-l-phenyl-5-thioxo-l,5-dihydro-4//-pyrazol-4-one quinolin-8-ylhydrazone (HL ) and (4Z)-5-methyl-2-phenyM-[(quinolin-8-ylimino)methyl]-2,4-dihydro-3//-pyrazole-3-thione (HL ) were synthesized <2005RCB633>. 

Michael condensation of 1 and frans-/)-benzoylacrylic acid afforded butanoic acid derivative 315 that can be cyclized, with ammonia in an autoclave at 150-160 °C, to give 7,7-dimethyl-4-phenyl-l,2,6,7,8,8a-hexahydro-pyrrolo[4,3,2-d,e]quinolin-2-one (316) (97JOU1048). The pyr-rolo[3,4-fr]quinoline 317 was reported as inhibitor of Aurora A Kinase (07EUP60) (Scheme 59). 

AaC = 2-amino-9Tf-pyrido[2,3-fe]indole MeAaC = 2-amino-3-methyl-9Tf-pyrido[2,3-fe]indole Glu-P-1 = 2-amino-6-methyldipyrido[l,2-a 3 ,2 -ai] imidazole Glu-P-2 = 2-aminodipyrido[l,2-a 3 ,2 -ii]imidazole PhIP = 2-amino-l-methyl-6-phenyl-lH-imidazo[4,5-i)]pyridine IQ = 2-amino-3-methyl-3//-imidazo[4,5-/ quinoline MelQ = 2-amino-3,4-dimethyl-3Tf-imidazo[4,5-/ quinoline Trp-P-1 = 3-amino-l,4-dimethyl-5Tf-pyrido[4,3-i)]indole Trp-P-2 = 3-amino-l-methyl-5//-pyrido[4,3-I>]indole. 

Step G 4-[Ortho-(2, 3 -Dihydroxypropyloxycarbonyl)-Phenyl]-Amino-S-Trifluoromethyl-quinoline Acetonide - 100 cc of toluene were added to 80 cc of 2,2-dimethyl-4-hydroxy-methyl-1,3-dioxolane and the toluene was distilled off under reduced pressure to eliminate the water present. To the anhydrous 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane thus obtained, 0.25 gram of an oily 50% suspension of sodium hydride and then 21.3 grams of 4-... 

RZC345). When 23 was heated together with nitrobenzene cyclization to 3-methyl-l-phenylpyrazolo[3,4- ]quinoline 26 occurred. Tomasik et al. have reported some analogs of 26 from 2-aminobenzaldehyde and l-methyl-3-phenyl-, 1,3-dimethyl-, 1,3-diphenyl pyrazolin-5-one and p) -azolone in 20-60% yields (Scheme 9) (83JHC1539). 

LIN, A.J., B.J. LILLIS, A.C. SARTORELLI. 1975. Potential bioreductive alkylating agents. 5. Antineo-plastic activity of quinoline-5,8-dione, naphtha-zarine and naphthoquinones. J. Med. Chem. 18 917. LIN, A.J., A.C. SARTORELLI. 1976. Potential bioreductive alkylating agents. 7. Antitumor effects of phenyl-substituted 2-chloromethyl-3-phenyl-1,4-naphthoquinones. J. Med. Chem. 19 1336. LIN, A.J., A.C. SARTORELLI. 1973. 2,3-Dimethyl-5,6-... 

Triethanolamine, Triiso-propanolamine p-Diethylaminoethanol Pyrrolidine Piperidine, N-Ethyl-Dialkyl-, Dimethyl-, piperidine, N-Methyl-, N-Phenyl-morpholine Aniline, Benzidine Diethyl-aniline 1,4-Dihydropyridines Pyridine, Lutidine, Collidine, Quinoline Brucine... 

Ci bHi 7NO3, 1, 2,3,9b-Tetrahydro-9bp-hydroxy- 2/3-methoxy-1a-phenyl-5H-pyrrolO [2,1-a]isoindol-5 One, 46B, 277 ClbHigBrNjO, 1-Methyl-2-phenyl-5,10-dihydro-1H-imidazo[2,1-b]iso-quinolin-4-ium bromide monohydrate, 43B, 366 ClbHigBrN On, 4-Ethoxycarbonyl 5 p-bromooxoben20yl-8,8-dimethyl-3,4,9,1O-tetraazatricyclo[5.3.0.0 ]deca-2,9-diene, 40B, 275 CiBHigBr3N203, 11,12,13-Tribromo-3,6-diethyl-1O-ethoxycarbonyl-3,6-diazatricyclo[7.4.0.0 " ]trideca-2(7),9,11,13-tetraene-8-one, 46B, 277... 

---