Quinoline 2,3-dihydro

Acetone anil Acetone anil (quinoline deriv.) Agerite resin 0 AI3-17714 CCRIS 4795 EINECS 205-688-8 Flectol A Flectol H Flectol pastilles HSDB 1103 NCI-C60902 NSC 4175 Polnox R Quinoline. 1,2-dihydro-2,2,4-trimethyi- Trimethyl dihydroquinoline Trimethyl-1,2-dihydroquinoline Vulkanox HS/LG Vulkanox MS/powder. 

Naphtho[l,2-h]pyrylium salts, 5,6-dihydro-2,4-diphenyl-synthesis, 3, 869 Naphtho[2,l-h]pyrylium salts synthesis, 3, 866 Naphthoquinolines, tetrahydro-synthesis, 2, 469 N aphtho[ 1,2-7]quinolines Skraup synthesis, 2, 467... 

H,4H-Oxazolo[5,4,3-y]pyrido[3,2-g]quinolin-4-one, 8-hydroxymethyl-6-methyl — see Nybomyein 5H-Oxazolo[2,3-[Pg.731]

Friedlander synthesis, 2, 445 Quinoline, alkenyl-1,2-dihydro-disproportionation, 2, 369 Quinoline, 2-alkoxy-reactions, 2, 351 Quinoline, 4-alkoxy-reactions, 2, 351 Quinoline, 2-alkoxy-4-hydroxy-synthesis... 

Quinoline, 2-(N-methylcarboxamido)-conformation, 2, 111 Quinoline, 2-methyl-1,2-dihydro-Doebner-von Miller synthesis, 2, 466 Quinoline, 2-methyl-2,4-diphenyl-1,2-dihydro-synthesis, 2, 476... 

Quinoline, 2,2,4-trimethyl-1,2-dihydro-antioxidant in polymers, 1, 395 Doebner-von Miller synthesis, 2, 468 Quinoline, trimethylstannyl-reactions, 2, 364 Quinoline, 4-vinyl-polymers, 1, 286... 

Quinolin-2-one, 3-cyano-4-hydroxy-synthesis, 2, 428 Quinolin-2-one, 3,4-dialkyl-Knorr synthesis, 2, 425 Quinolin-2-one, dihydro-Camps synthesis, 2, 418 synthesis, 2, 402 from benzazepinones, 2, 506 from indanone oxime, 2, 487 from indanones, 2, 488 by intramolecular Friedel-Crafts reactions, 2, 421... 

The directions of rotation at C and C have been arrived at from the following considerations. The deoxy-bases (II p. 443 Q = quinoline residue) obtained from cinchonine and cinchonidine are structurally identical, i but optically different, and since they must be optically identical at C and C, and C is no longer asymmetric, the difference between them (see table, p. 446) must be due to difference in direction of rotation at C , which must therefore be dextrorotatory in cinchonine and laevorotatory in cinchonidine, and this must also be true of quinidine and quinine respectively and of the corresponding dihydro-bases. The keto-bases, cinchoninone and quininone, might be expected to exist each in two pairs, since carbon atom 8 is, according to the formula (p. 442), asymmetric, but it is better represented by the tautomeric grouping —... 

The nitration of l,2,5-selenadiazolo[3,4-/] quinoline 77 with benzoyl nitrate affords the 8-nitro derivative 78, whereas methylation with methyl iodide or methyl sulfate afforded the corresponding 6-pyridinium methiodide 79 or methosulfate 80, respectively (Scheme 29). The pyridinium salt 80 was submitted to oxidation with potassium hexacyanoferrate and provided 7-oxo-6,7-dihydro derivative 81 or, by reaction of pyridinium salt 79 with phenylmagnesium bromide, the 7-phenyl-6,7-dihydro derivative 82. Nucleophilic substitution of the methiodide 79 with potassium cyanide resulted in the formation of 9-cyano-6,9-dihydroderivative 83, which can be oxidized by iodine to 9-cyano-l,2,5-selenadiazolo [3,4-/]quinoline methiodide 84. All the reactions proceeded in moderate yields (81IJC648). 

Selenium dioxide oxidation of 7,8-dihydro-5(6//)-quinolinone semicarbazone gave, in addition to the expected 4,5-dihydro selenadiazoloquinoline 95 (analogous to sulfur derivative 76), the oxidized l,2,3-selenadiazolo[4,5-/]quinoline 96, which, when heated to 210°C for 30 min, gave the dimeric [l,4]diselenino [2,3-/ 5,6-/ ]diquinoline (95JHC177). 

Trialkyl-2,3-dihydro-l//[l,4]diazepino[2,3-/]quinolines 109, obtained from the reaction of 5,6-diaminoquinoline with ketones, on treatment with acid or under thermal conditions afforded solely the 2-methyl-3//-imidazo[4,5-/]quino-line 110. However, no change was observed when diazepinoquinolines were treated... 

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