Quinoline and Acridone Alkaloids

Non-hemiterpenoid Quinolines.—Extraction of the leaves and fruit of Evodia rutaecarpa resulted in the isolation of three 2-(n-alkyl)-l-methyl-4-quinolones, dihydroevocarpine (1 R = Me, n= 12), the pentadecyl derivative (1 R = Me, n = 14), and the undecylquinolone (1 R = Me, n = 10). The structures of the three 

A considerable number of new quinoline and acridone alkaloids has been identified and the recognition of two new groups of dimeric quinolinone alkaloids is of particular interest. There has been little activity in the quinazoline alkaloid area and this section is omitted this year. 

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Quinoline and Acridone Alkaloids.—Earlier studies have shown that the quinoline nucleus of skimmianine (38) and dictamnine (37) is derived from anthranilic acid and acetate. Whilst incorporation of mevalonate into dictamnine in Dictamnus albus and into the furanoquinoline alkaloids of Skirnmia japonica could not be demonstrated, positive results have been obtained in Fagara coco. [4- " C]Mevalonic acid, [5- " C]mevalonic acid, and [l- " C]dimethylallyl alcohol were satisfactorily incorporated into skimmianine (38) and the activity was confined essentially to C-2, C-3, and C-3 respectively. 

Grundon MF (1983) Quinoline and acridone alkaloids. In The alkaloids, vol 13. The Chemical Society, London, pp 99-121... 

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