Quinazolines Niementowski quinazoline synthesis

Niementowski quinazoline synthesis. Formation of 4-oxo-3,4-dihydroquinazolines by cycli-zation of the reaction products of anthranilic acid and amides. 

The striking improvement in the Niementowski quinazoline synthesis [156, 157] has been fulfilled using microwave irradiation by Besson et al. [158,159] (Scheme 7). Using microwave irradiation and/or Appel s salt, new efficient routes to various substituted and fused quinazolines have been developed by Besson et al. [158,159] and also by others [ 160,161]. 

Scheme Microwave-assisted Niementowski quinazoline synthesis [158,159]...

Niementowski Quinazoline Synthesis Richard A. Hartz 8.4.1 Description... 

The Niementowski quinazoline synthesis is the condensation of an anthranilic acid (1) with an amide (2) to produce a 4-keto-3,4-dihydro-quinazoline product (3). The reaction occurs under thermal conditions, and reaction temperatures > 100 °C are generally required. This reaction is also often referred to as the Niementowski reaction, and occasionally as the Niementowski 4-quinazolone synthesis or von Niementowski synthesis. ... 

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