Quinapril Cimetidine

Oats Sitagliptin, cimetidine, ibuprofen, quinapril, indapamide, adefovir, cidofovir, tenofovir, cephalosporin, torsemide... 

Cimetidine did not appear to alter the pharmacokinetics or pharmacological effects of captopril or enalapril, or the pharmacokinetics of fosinopril or quinapril in studies in healthy subjects. The manufacturers of cilazapril say that no clinically significant interaction occurred with H2-receptor antagonists (not specifically named) and the manufacturers of moexipril, " ramipril, and trandolapril say that no important pharmacokinetic interaction occurred with cimetidine. The manufacturers of spirapril briefly note in a review that cimetidine did not alter the plasma concentrations of spirapril or its active metabolite spiraprilat. None of these pairs of drugs appears to interact to a clinically relevant extent, and no special precautions appear to be necessary. 

Ferry JJ, Cetnarowski AB, Sedman AJ, Thomas RW, Horvath AM. Multiple-dose cimetidine administration does not influence the single-dose pharmacokinetics of quinapril and its active metabolite Cl-92Z).J ClinPharmacol (1988) 28, 48-51. 

Anastrozole does not appear to interact with aspirin, cimetidine, digoxin, oral antidiabetics or quinapril. It also appears to have no effect on cytochrome P450 enzymes, so it is unlikely to interact with drugs that are affected by enzyme inducers or inhibitors. 

In a pharmacokinetic study, 10 elderly women with breast cancer were given anastrozole 1 mg daily for 10 weeks and 5 of them who also had hypertension were additionally given quinapril, after week 4, for 28 days. Quinapril did not affect plasma anastrozole levels and dose modification is not required during concurrent use. A clinical study with cimetidine has shown that it does not affect the pharmacokinetics of anastrozole, which suggests that anastrozole is unlikely to be affeeted by other drugs that inhibit cytochrome P450. Another clinical study showed that anastrozole does not affect the pharmacokinetics of antipyrine (phenazone), so that it is unlikely to interact with those drugs which are known to be affected by enzyme inducers and inhibitors. 

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