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Quazepam

Quazepam (88) has a highly fluorinated sidechain so as to make this tranquilizer resistant to dealkylation. It also incorporates a lipid-solubilizing 2-thione moiety. The synthesis begins with bi aryl ketone derivative by ] -al kylation with 2,2,2-trifluoroethyltriclate to give 86. [Pg.196]

Next the product is acylated with bromoacetyl chloride and the glycine equivalent is constructed in place by a Gabriel amine synthesis (phthalamide anion followed by hydrazine) subsequent to which cyclization to benzodiazepine occurs. The synthesis of the tranquilizer quazepam (88) is finished by thioamide conversion with phosphorus pentasulfide. ... [Pg.197]

CijHijClFNO 784-38-3) see Cinolazepam Doxefazepam Ethyl loflazepate Flunitrazepam Flurazepam Flutazolam Midazolam Quazepam... [Pg.2291]

C2H5N 151-56-4) see Carboquone Levamisole Medazepam Quazepam Thiotepa Triaziquone... [Pg.2301]

C2H2BrC10 22118-09-8) see Cloxazolam Flurazepam Mexazolam Nazasetron Quazepam Salbutamol... [Pg.2311]

CfiHfiClN 106-47-8) see Acetarsol Alprazolam Diazepam Efavirenz Flunitrazepam Flutoprazepam Medazepam Quazepam... [Pg.2323]

Quazepam (Doral ) 2 2 5—41 7.5-15 Oxidation N-dealkylation 2-Oxo-quazepam N-DAFa High risk of hangover and residual effects... [Pg.627]

The effects of flurazepam and quazepam are long because of active metabolites. [Pg.830]

Tolerance to hypnotic effects develops after 2 weeks of continuous use of triazolam. Efficacy offlurazepam, quazepam, and temazepam lasts for at least 1 month of continuous nightly use. Estazolam reportedly maintains efficacy at maximum dosage (2 mg nightly) for up to 12 weeks. [Pg.831]

There is an association between falls and hip fractures and the use of long-elimination half-life benzodiazepines thus, flurazepam and quazepam should be avoided in the elderly. [Pg.831]

The benzodiazepines that have been most commonly marketed as sedative-hypnotics include temazepam (Restoril), estazolam (ProSom), flurazepam (Dalmane), quazepam (Doral), and triazolam (Halcion). Of these five, temazepam is the most easily metabolized and eliminated. Therefore, temazepam is preferred for elderly and medically ill patients to minimize the risk of drug accumulation. [Pg.269]

See other pages where Quazepam is mentioned: [Pg.835]    [Pg.223]    [Pg.258]    [Pg.276]    [Pg.245]    [Pg.237]    [Pg.239]    [Pg.240]    [Pg.1765]    [Pg.1765]    [Pg.2329]    [Pg.2335]    [Pg.2337]    [Pg.2337]    [Pg.2337]    [Pg.2386]    [Pg.2449]    [Pg.596]    [Pg.617]    [Pg.597]    [Pg.619]    [Pg.59]    [Pg.267]    [Pg.133]    [Pg.273]    [Pg.49]    [Pg.356]    [Pg.1307]    [Pg.1593]   
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