Quasi-species models limitations

There are, however, more principal limitations, and it is important to stress that the quasi-species model is a particular model holding only where its prerequisites are fulfilled. The linear autocatalytic rate law is one of the prerequisities typical for the quasi-species nature. If rates become independent of the concentrations of growing substraces, coexistence may replace competition, or if, on the other hand, the autocatalytic rate law depends more... 

The typical outcome of quasi-species behavior is natural selection in the Darwinian sense. We believe that it should be possible to adapt the quasispecies model to any situation where natural selection in the Darwinian sense plays a major role. Hence the model may be generalized so as to include all kinds of horizontal gene transfer typical for recombination. The model as presented is essentially a deterministic model that holds only for a sufficiently large population size. This limitation and a possible way to overcome it will be the subject of the final section. 

Assuming a uniform accessibility of the tip surface, e.g., a uniform concentration of electroactive species, an analytical approximation of the tip feedback current can be derived (see Chapter 5). For convenience, we repeat the main equations here. Such a model represents a thin layer cell (TLC) with a diffusion-limiting current expressed by Eq. (8). The approximate equation for a quasi-reversible steady-state voltammogram is as follows (11) ... 

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