Quasi-racemic FMS

Enantiopure or enantioenriched compounds can be obtained by asymmetric synthesis or by separation of a racemic reaction mixture. Quasi-racemic FMS provides a new approach to enantiomeric compounds (see Scheme 13.2) [26, 27]. Quasi-racemic synthesis starts with two individual R- and 5-enantiomers attached to two different fluorous tags. After steps of mixture synthesis followed by F-HPLC demixing and detagging, two individual products as enantiomers are obtained (see Sections 13.2.1 and 13.2.2). The separation and identification of the final quasi-enantiomers are ensured by the phase-tag-based F-HPLC. In a more complicated quasi-racemic FMS, additional enantiomerically pure building blocks and fluorous tags can be used to generate more chiral centers and more than two products as stereoisomers (see Sections 13.2.3 to 13.2.8). 

Scheme 13.4 Quasi-racemic FMS of (S)- and (R)-pyridovericins. 13.2.2 Synthesis of Enantiomers of Mappicine...

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