Quantum mechanics, in computational chemistry

Since the time of Corey s work both experimental and computational methods have advanced very much. The use of modem NMR methods makes it much easier to unravel conformational details experimentally than was possible in the 1950s. The advent of quantum mechanics in computational chemistry, and the availability of computers to solve real problems by that method, has made it easier for us to understand in considerably more detail just what is involved in problems of this nature. Further, by modeling this type of problem with molecular mechanics, we can also quantitatively understand the problem in the familiar terms of physical organic chemistry. 

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