Quantitative In vitro Radiolabeled Reaction Phenotyping Studies

1 Quantitative In vitro Radiolabeled Reaction Phenotyping Studies 

Experimental methodologies utilizing radiolabeled compound are similar to those where authentic standard is available (see Section 15.6.3). Radiolabeled studies can be conducted using the following expressed enzyme and/or human liver microsomes for the evaluation of A m-V max chemical inhibition, and/or correlation analysis using a characterized bank of human liver microsomes (Tuvesson et al., 2005 Zhu et al., 2005 Zhang et al., 2007). 

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