Pyuria indinavir

Of 23 indinavir-treated patients with persistent pyuria, four had interstitial nephritis, seven had urothelial inflammation, 10 had both interstitial nephritis and urothelial inflammation, and two had non-specific urinary tract inflammation (26). In all, 21 patients had multinucleated histiocytes identified by cytological testing of urine specimens. Urine abnormalities resolved in all 20 patients who stopped taking indinavir, and pyuria persisted in the other 3. Six patients had raised serum creatinine concentrations, which returned to baseline when indinavir was withdrawn. 

Sarcletti M, Petter A, Romani N, Ehotta K, Konig P, Maier H,and Zangerle R. Pyuria in patients treated with indinavir is associated with renal dysfunction. Clinical Nephrology 54 261-270,2000. 

Patients with indinavir crystalluria may be asymptomatic or can develop clinical symptoms such as flank pain, back pain, dysuria, urinary urgency, fever, nausea, and vomiting. Pyuria and hematuria (commonly microscopic) may also be seen [131-133, 135-137, 138]. Indinavir crystals (Figure 1) are variable in their appearance by microscopy, usually with needle-shaped, plate-like, fan-shaped, or starburst-like appearances [131,133]. Ultrasound imaging is emerging as imaging modality of choice and may be more... 

Perazella MA, Kashgarian M, Cooney E. Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria. Clin Nephrol 1998 50 194-196. 

Patients with indinavir crystalluria may be asymptomatic or develop clinical features of renal colic, flank or back pain, dysuria, urinary urgency, fever, nausea and vomiting. Pyuria and microscopic or, less corn-... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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