Pyrroline carboxylate

Proline is oxidised to form pyrroline-5-carboxylate, and FAD is the hydrogen acceptor. The pyrroline-5-carboxyl-ate is converted, via several reactions, to glntamate ... [Pg.160]

Maleylacetoacetate Fumarylacetoacetate Acetoacetate ( Glutamate 4-semialdehyde A -Pyrroline-5-carboxylate... [Pg.415]

This enzyme [EC 1.5.1.12] catalyzes the reaction of 1-pyrroline-5-carboxylate with NAD+ and water to produce L-glutamate and NADH. The enzyme will also act on 3-hydroxy-l-pyrroline-5-carboxylate to generate 4-hy dr oxy glutamate. [Pg.591]

He isoleucine, Kyn kynurenine, Leu leucine, Lys lysine, Met methionine, MTHFR 5,10-methylene tetrahydrofolate reductase, Orn ornithine, p plasma, P5C pyrroline-5-carboxylic acid, PEA phosphoethanolamine, Phe phenylalanine, P-Hyl O-phosphohydroxylysine, Pip pipecolic acid, Pro proline, Sacch saccharopine, Sar sarcosine, Ser serine,... [Pg.81]

Pyrroline-5-carboxylate synthase deficiency p Prof, Ornj, Citp, ArgP... [Pg.82]

ASA-lyase deficiency Pyruvate carboxylase deficiency LPI Pyrroline-5-carboxylate synthase deficiency... [Pg.84]

One route of catabolism of proline is essentially the reverse of its formation from glutamate. Proline oxidase yields A -pyrroline 5-carboxylate.145a,b... [Pg.1374]

The corresponding open-chain aldehyde, formed by hydrolysis, can be oxidized back to glutamate by pyrroline 5-carboxylate dehydrogenase. 145a 147 Lack of this enzyme is associated with the human genetic deficiency causing hyperprolinemia.147-1483... [Pg.1374]

Oxaloacetate + Glutamate Glutamate + NH3 Glutamate + NAD+ + H20 Succinate semialdehyde + Glutamate Pyruvate + Glutamate A1-Pyrroline 5-carboxylic acid... [Pg.6]

Fig. 1.3 Reactions showing synthesis of glutamate in brain. Aspartate aminotransferase (1) glu-taminase (2) glutamate dehydrogenase (3) GABA aminotransferase (4) alanine aminotransferase (5) ornithine aminotransferase (6) Al-pyrroline 5-carboxylic acid dehydrogenase (7) and asparagine synthetase (8)...

A. Pyrimine (L-5(2-pyridyl)-2-amino-5-ketopentanoic acid l-2(2-pyridyl)-A1-pyrroline-5-carboxylic acid 119)... [Pg.98]

Hyperprolinemia II Unclear Proline <5-Pyrroline-5-carboxylate dehydrogenase... [Pg.572]

However, following its formation, the semialdehyde undergoes a spontaneous cyclization and is converted to a A -pyrroline-5-carboxylic acid (P5C), a proline precursor. [Pg.247]

Glutamic y-semialdehyde cyclizes with a loss of H2O in a nonenzymatic process to give A i-pyrroline-5-carboxylate, which is reduced by NADPH to proline. Alternatively, the semialdehyde can be transaminated to ornithine, which is converted in several steps into arginine (Section 23.4.1). [Pg.996]

Hyperprolinemia. typell 239510 Delta 1 Pyrroline-.. ... 5-carboxylate dehy-. drogenase <1 100,000) Mental retardation, seizures in early life. /... [Pg.2214]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...