Pyrophosphoric acid diesters

Acetonitrile s. under CHgOCH Cl Monochloromethyl ether acetonitrile Sym. pyrophosphoric acid diesters from phosphoric acid monoesters... 

Pyrophosphoric acid diesters from phosphoric acid monoesters... 

Pyrophosphoric acid diesters. A soln. of phenyl dihydrogen phosphate, di-phenylmercury, and tri-n-butylphosphine in anhydrous benzene refluxed 3 hrs.. 

Full details of the synthesis of unsymmetrical diesters of pyrophosphoric acid by the reaction of the disilver salt of a monoester of phosphorothioic acid and a phosphate monoester have been published. In view of the good yields, the mild conditions, and the absence of symmetrical pyrophosphate byproducts it appears to be superior to previous routes to the nucleotide pyrophosphate coenzymes. Further, the findings that the procedure is insensitive to... 

The main purpose of this section is to introduce derivatives of phosphoric acid. The acid chloride derivative is C1P0(0H)2, chlorophosphoric acid, and the amide derivative is phosphoramic acid, HgN-POCOHlg. These acid derivatives will not be discussed because they will not be used in this book. There are three ester derivatives of phosphoric acid a monoester 203, a diester 204, and a triester 205. There are also derivatives of pyrophosphoric acid (diphosphoric acid, 206), which include various esters. 

Pyrophosphoric acid P P -diesters are activated by trichloroacetonitrile and become phosphorylation agents.—E A soln. of pyridinium di-p-chlorophenyl pyrophosphate in pyridine treated with n-propanoi and trichloroacetonitrile, kept 24 hrs. at 70 , and the product isolated as the cyclohexylammonium salt cyclohexylammonium p-chlorophenyl n-propyl phosphate. Y 92%. F. e. s. F. Gramer, K.-H. Scheit, and H.-J. Baldauf, B. 95, 1657 (1962). 

Esters of phosphoric acid, pyrophosphoric acid, and triphosphoric acid are important biological molecules. Each OH group of the acid can be esterified monoesters and diesters are the most common biological molecules. ATP is a monoester of triphosphoric acid. We have seen that the components of cell membranes are monoesters or diesters of phosphoric acid (Section 16.13), and that many of the coenzymes are monoesters or diesters of either phosphoric acid or pyrophosphoric acid (Chapter 24). In Section 26.1, we will see that DNA and RNA are diesters of phosphoric acid. 

Phosphoric acid diesters from phosphorodichloridates—Simultaneous removal of protective groups s. 13, 284 Pyrophosphoric acid esters... 

Phosphoric acid diesters s. 17, 171 also unsym. pyrophosphoric acid esters s. Soc. 196A, 326... 

Corby, N S, Kenner, G W, and Todd, A R (1952) The preparation of tetra-esters and pyrophosphoric acid from diesters of phosphoric acid by means of exchange reactions. J. Chem. Soc. (Lond.) 1234-1243... 

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