Pyrimidines/pyrimidine nucleotides metabolism

Volume LI. Purine and Pyrimidine Nucleotide Metabolism Edited by Patricia A. Hoffee and Mary Ellen Jones... 

S. Haste, E. De Clercq, and J. Balzarini Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation. Biochemical Pharmacology 58,539 (1999). 

See also De Novo Biosynthesis of Purine Nucleotides, De Novo Pyrimidine Nucleotide Metabolism, Nucleotide Salvage Synthesis... 

See also Regulation of Enzyme Activity, Pyrimidine Nucleotide Metabolism (from Chapter 22), Figure 22.10... 

Pyrimidine Nucleotide Metabolism, Nucleotide Salvage Synthesis... 

Figure 22.11 Catabolic pathways in pyrimidine nucleotide metabolism. 

See also The Importance of PRPP, De Novo Biosynthesis of Purine Nucleotides, Excessive Uric Acid in Purine Degradation, De Novo Pyrimidine Nucleotide Metabolism, Nucleotide Salvage Synthesis, Deoxyribonucleotide Biosynthesis, Biosynthesis of Thymine Deoxyribonucleotides, Salvage Routes to Deoxyribonucleotide Synthesis... 

Keppler, D. and Holstege, A. (1982) Pyrimidine nucleotide metabolism and its compartmen-tation. In Metabolic Compartmentation (ed. Sies, H.), Academic Press, London, pp. 147-203. 

Microorganisms utilize pyrimidine bases for incorporation into polynucleotides, and studies with bacteria and yeasts have been central in the elucidation of the enzymatic sequences of pyrimidine nucleotide metabolism (see review, reference 7). 

The expression may require bromodeoxyuridine as in the case of fragile site 10q25 or may also involve replacement of thymidine with deoxyuridine as indicated with studies on fragile site Xq27. Further studies of pyrimidine nucleotide metabolism and incorporation into DNA may clarify the molecular and hereditary bases of fragile chromosome site expression. 

Devlin, T. M. (ed.). 1997. Purine and pyrimidine nucleotide metabolism. In Textbook of Biochemistry with Clinical Correlations (4th ed.). Chapter 12,489pp. New York Wiley-Liss. 

Proteias are metabolized coatiauously by all living organisms, and are ia dyaamic equilibrium ia living cells (6,12). The role of amino acids ia proteia biosyathesis has beea described (2). Most of the amino acids absorbed through the digestioa of proteias are used to replace body proteias. The remaining portioa is metabolized iato various bioactive substances such as hormones and purine and pyrimidine nucleotides, (the precursors of DNA and RNA) or is consumed as an energy source (6,13). 

Figure 20-7. Summary of the interrelationships in metabolism of amino sugars. (At asterisk Analogous to UDPGIc.) Other purine or pyrimidine nucleotides may be similarly linked to sugars or amino sugars. Examples are thymidine diphosphate (TDP)-glucosamine and TDP-N-acetylglucosamine.

Goordinated regulation of purine and pyrimidine nucleotide biosynthesis ensures their presence in proportions appropriate for nucleic acid biosynthesis and other metabolic needs. 

The RBC contains certain enzymes of nucleotide metabolism (eg, adenosine deaminase, pyrimidine nucleotidase, and adenylyl kinase) deficiencies of these enzymes are involved in some cases of hemolytic anemia. 

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