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Pyrimidines, 5-amino-4-hydrazino

A hydrazine or substituted hydrazine in lieu of the amino group on the pyrimidine precursor is also an effective species. In what may be described as a Fischer indole-type reaction, 2-amino-6-hydrazino-4(3//)-oxopyrimidine 129 undergoes thermolytic cyclization when heated with compounds 130 (Scheme 12). The resultant product 131 is obtained in modest yield <1996H(43)323, B-2002MI439>. [Pg.361]

Amino-2-hydrazino-4(3//)-pyrimidinone (397) and orthoesters in hot acetic acid or BuOH gave l,2,4-triazolo[4,3-a]pyrimidin-7(8//)-ones 398. When the heating in acetic acid was continued overnight, the acetamido derivative 399 was obtained. In acetic acid at room temperature, the re-... [Pg.177]

Another way to prepare 2-amino derivatives is by the reaction of 2-methylthio-4-oxo-4// derivatives with amines.268,288 The 2-methylthio-4-imino derivative reacted differently (see Section III,C,8). 2-Ainino-4-oxo-4//-pyrido[l,2-a]pyrimidine could have also been prepared by reducing the 2-hydrazino derivative with hydrogen sulfide.289... [Pg.300]

As part of their study on aza-transfer reactions, Tisler and co-work-ers289 290 reacted 2-hydrazino-4-oxo-4//-pyrido[l,2-u]pyrimidine with various diazo derivatives and obtained 2-azido- and 2-amino-4-oxo-4/f-pyrido[l,2-u]pyrimidines. From 2-azido-4-oxo-4/f-pyrido[l,2-u]pyrimi-dines various derivatives of 2-(l,2,3-triazol-l-yl)-4-oxo-4//-pyrido[1.2- ]-pyrimidine (221) were prepared by reaction with acetylene,287 1,3-dioxo compounds,166 ordiethylamine.291 For further ring transformation reactions of the 2-azido-4-oxo-4//-pyrido[l,2- ]pyrimidine (102), see Section lll.C.lO. [Pg.301]

The tetracyclic systems, triazolothienopyrimidines, tetrazolothienopyrimidines, and related tetrazepino derivatives, were obtained from 2,3,5,6,7,8-hexahydro-3-amino-2-hydrazino-l-benzothieno[2,3-<7]pyrimidine-4(37/)-one <1995PS85>. [Pg.550]

Pyrimidin, 2-Amino-4-hydrazino-6-hydroxy-5-nitro- E16a, 725 (Cl -tNH-NHj)... [Pg.156]

Pyrimidin 5-Amino-2-chlor-4-hydrazino-6-trifluormethyl-E16a, 733 (Cl - NH-NH2)... [Pg.196]

Pyrimidin 2-Amino-6-chlor-4-(l-methyl-hydrazino)- El6a, 731 (Cl - NR-NH2)... [Pg.211]

Pyrimidin 2-Amino-6-hydroxy-4-[l-(2-hydroxy-ethyl)-hydrazino]-E16a, 727 (Cl - NR —NH2)... [Pg.308]

H-< 1,2,4-Oxadiazolo[4.3-a]-l,3,5-triazin) 5,7-Dimethyoxy-3,3-dimethyl- E16c, 221 (aus Azido-1.3,5-triazin) Pyrimidin 5-Ethoxycarbonyl-4-hydrazino-2-hydroxy-6-methyl-E16a, 766 (SH - NH-NH2) 2H-l,2,3-Triazol 5-(Diethoxy-methylen-amino)-4-formyl- E4, 565 [C(OR)4 + Amin]... [Pg.512]

Cyclohexyl-ethyl)- -Hydrochlorid Elba. 449 (Hydrazon-Red.) 2-Cyclohexyl-l-(2-hydroxy-ethyl)-Elba, 516 (Hydrazon + H2) 2-Penten l-Hydrazino-2,4,4-trimethyl- X/2, 55 Piperazin 1,4-Diethyl- XI/1, 221 Pyrazolidin 1,2,3,5,5-Pentamethyl-E16a, 576 (Hydrazonium-Red.) Pyrimidin 1,3-Diethyl-hexahydro-E14a/3, 609 (CO CH2) Pyrrolidin 1-(4-Amino-butyl)- IV/lc, 121... [Pg.554]

Pyrimidin 6-Amino-2,4-dioxo-3-phenyl-l,2,3,4-tetrahydro- E15/2, 2228 [ —R—OH(Cyclokond.)] lH- 6-Nitro-2,3-dihydro- IV/la, 182 Quinolin 4-Hydrazino-6,7-methylen-dioxy- E16a, 700 (Cl - NH-NH2) Quinolin-l-oxid 2-Amino-3-aminocarbonyl- E7a, 504 [2-N02 - Ar -CH = C(CN) -CO —NH2/Pt]... [Pg.721]

Pyrimidin 4-Amino-2-hydrazino-5-(2-hydroxy-4-nitro-phenyI)-E16a, 795 (R —NH —N02-Red.)... [Pg.733]

Pyrimidin 4-Amino-6-hydrazino-5-nitro-2-(2-phenyl-ethenyl)- E16a, 725 (Cl NH-NH2)... [Pg.998]

Phenacyl bromides react (86JHC43) with anhydro l-amino-5-aryI-2-mercapto-l,2,4-triazolo[3,2-c]quinazolin-4-ium hydroxides (53) through pyrimidine ring-opening and simultaneous formation of the 1,3,4-thiadiazine nucleus to give 54. Compound 514 was also obtained [86JAP(K)61260085] when 2-hydrazino-5-methyl-6/f-l,3,4-thiadiazine (513) was cyclized with aryloxyacetyl chlorides. [Pg.361]


See other pages where Pyrimidines, 5-amino-4-hydrazino is mentioned: [Pg.85]    [Pg.87]    [Pg.291]    [Pg.801]    [Pg.232]    [Pg.233]    [Pg.148]    [Pg.203]    [Pg.85]    [Pg.87]    [Pg.291]    [Pg.801]    [Pg.115]    [Pg.232]    [Pg.355]    [Pg.822]    [Pg.824]    [Pg.378]    [Pg.348]    [Pg.232]    [Pg.85]    [Pg.87]    [Pg.291]    [Pg.215]    [Pg.275]    [Pg.376]    [Pg.857]    [Pg.1035]   


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2-Hydrazino

Pyrimidine amino

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