Pyrimidine, 2,4,5-trichloro-6-methyl

Pyrazolo[l,5-a]pyrimidine-6-carboxylates (1402) were prepared in 70% yields in the reaction of 3-aminopyrazoles and diethyl amino(trichloro-methyl)methylenemalonate in boiling ethanol in the presence of sodium ethoxide for 6 hr (78JPR533). 

Some 1-carbonyl-3-methyl-2-pyrazoline-4,5-dione-4-arylhydrazones are active against Trichinella spiral is. 3 Against microfilarial infections, 2-ethyl-6-methyl-2,3,4,4a,5,6,7,8-octahydro-lH-pyrazino(l,2-c)pyrimidine-l-one seems to be very promising.0,0-Dimethyl-2,2,2-trichloro-l-hydroxyethylphosphonate, a choline esterase inhibitor, immobilizes the adult Onchocerca volvulus and consequently is useful in treating onchocerciasis. 1 8... 

Stone). In the last-named situation, where there will be likely exposure to a mixture of OPs, there is a serious problem in that the biological significance of the findings will be unclear. Furthermore, alkyl phosphates may be present in the environment (presumably from biotic or abiotic degradation of OPs) so it cannot be assumed that all alkyl phosphate seen in human urine is derived from metabolism of OPs in humans. Substance-specific urinary metabolites can be measured as an alternative to, or in addition to alkyl phosphates,and one such is discussed above in relationship to propetamphos. Unlike the metabolite of propetamphos, which is an unusual alkyl phosphate, these are generally metabolites of the leaving group and include 2-isopropyl-6-methyl-pyrimidin-4-ol, a metabolite of diazinon, and 3,5,6-trichloro-2-pyridinol, a metabolite of chlorpyrifos. For a list of substance-specific urinary analytes available for seleeted OPs, see Jain. ... 

---