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Pyrimidine base structure

Nucleic acids are acidic substances present m the nuclei of cells and were known long before anyone suspected they were the primary substances involved m the storage transmission and processing of genetic information There are two kinds of nucleic acids ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) Both are complicated biopolymers based on three structural units a carbohydrate a phosphate ester linkage between carbohydrates and a heterocyclic aromatic compound The heterocyclic aro matic compounds are referred to as purine and pyrimidine bases We 11 begin with them and follow the structural thread... [Pg.1155]

All these findings, as well as the similarity of UV spectra - caused dioxotetrahydrotriazine to be classified as the simplest member of the formerly known 6-substituted derivatives. These derivatives are not interesting in connection with the analogs of natural pyrimidine bases and have been reviewed elsewhere. The structure of allantoxaidine and its appurtenance to the triazine series have been recently demonstrated by its unequivocal synthesis. [Pg.194]

The first chemical synthesis of these substances, using a procedure which yields 1-ribofuranosyl derivatives by pyrimidine bases, was described by Hall. By using the mercuric salt of 6-azathymine and tribenzoate of D-ribofuranosyl chloride, he obtained a mixture of two monoribosyl derivatives and a diribosyl derivative. He determined the structure of the 3-substituted derivative by the similarity of spectra and other properties to those of 3-methyl-6-razauracil. The structure of the 1-ribosyl derivative was then determined from the similarity of the spectra with 6-azathymine deoxyriboside obtained enzymatically. [Pg.215]

The DNA double heUx illustrates the contribution of multiple forces to the structure of biomolecules. While each individual DNA strand is held together by covalent bonds, the two strands of the helix are held together exclusively by noncovalent interactions. These noncovalent interactions include hydrogen bonds between nucleotide bases (Watson-Crick base pairing) and van der Waals interactions between the stacked purine and pyrimidine bases. The hehx presents the charged phosphate groups and polar ribose sugars of... [Pg.7]

The double-stranded structure of DNA can be separated into two component strands (melted) in solution by increasing the temperature or decreasing the salt concentration. Not only do the two stacks of bases puU apart but the bases themselves unstack while still connected in the polymer by the phosphodiester backbone. Concomitant with this denaturation of the DNA molecule is an increase in the optical absorbance of the purine and pyrimidine bases—a phenomenon referred to as hyperchromicity of denaturation. Because of the... [Pg.304]

Figure 11-6. Structures of representative conical intersections Sj/Sq in the pyrimidine bases, uracil, thymine, and cytosine. Uracil structures (a,d) are taken from Ref. [147, 210]. Thymine structures (b,e) are taken from Ref. [152], Cytosine structures (c,f) are taken from Ref. [157]... Figure 11-6. Structures of representative conical intersections Sj/Sq in the pyrimidine bases, uracil, thymine, and cytosine. Uracil structures (a,d) are taken from Ref. [147, 210]. Thymine structures (b,e) are taken from Ref. [152], Cytosine structures (c,f) are taken from Ref. [157]...
An introduction to the method of in vitro evolution is given by Wilson and Stoszak (1999). The RNA lipase ribozyme, with about 140 nucleotides (but without the pyrimidine base cytosine), folded in a defined structure and was able to reach a reaction rate 105 times higher than in the uncatalysed reaction. This result certainly surprised those biogenesis researchers who were critical of the RNA world but we do not know whether the result changed their attitude to it ... [Pg.164]

As in the case of pyrimidine bases discussed previously, adenine and guanine are subject to nucleophilic displacement reactions at particular sites on their ring structures (Figure 1.50). Both compounds are reactive with nucleophiles at C-2, C-6, and C-8, with C-8 being the most common target for modification. However, the purines are much less reactive to nucleophiles than the pyrimidines. Hydrazine, hydroxylamine, and bisulfite—all important reactive species with cytosine, thymine, and uracil—are almost unreactive with guanine and adenine. [Pg.58]

One of the most important reactions of purines is the bromination of guanine or adenine at the C-8 position. It is this site that is the most common point of modification for bioconjugate techniques using purine bases (Figure 1.53). Either an aqueous solution of bromine or the compound N-bromosuccinimide can be used for this reaction. The brominated derivatives then can be used to couple amine-containing compounds to the pyrimidine ring structure by nucleophilic substitution (Chapter 27, Section 2.1). [Pg.59]

Basic to molecular biology is the concept that DNA and RNA are macromolecules that convey information. The sequence of purine and pyrimidine bases in DNA encodes all the information needed to form and direct the chemical reactions within cells. This information thus encodes all catalytic, regulatory, and structural proteins contained within an organism. The flow of information from DNA to RNA to proteins is... [Pg.291]

The first direct evidence for the structure of platinum-blues was provided by the single-crystal X-ray studies of cis-diammineplatinum a-pyridonate-blue, [Pt(2.25+)4(NH3)8(/x-a-pyridonato-N,0)4] (N03)5 H20 (48, 49). In the study, Barton and Lippard selected a-pyridone as a simplified model of pyrimidine bases (see Fig. 3), which must be the primary reason of their success in obtaining the first crystalline-blue material. [Pg.379]

There are five common bases found in nucleic acids. Adenine (A), guanine (G) and cytosine (C) are found in both DNA and RNA. Uracil (U) is found only in RNA and thymine (T) only in DNA. The structures of these bases are shown in Figure 13.2. Adenine and guanine are purine bases while uracil, thymine and cytosine are the pyrimidine bases. [Pg.444]

C-Glycosides are typified by barbaloin, a component of the natural purgative drag cascara, but, as a group, the M-glycosides are perhaps the most important to biochemistry. Al-Glycosidic linkages are found in the nucleosides, components of DNA and RNA (see Section 14.1). In addition, nucleosides are essential parts of the structures of crucial biochemicals such as ATP, coenzyme A, NAD+, etc. The amine in these types of compound is part of a purine or pyrimidine base (see Section 14.1). [Pg.478]

The first evidence of the special structure of DNA was the observation that the amounts of adenine and thymine are almost equal in every type of DNA. The same applies to guanine and cytosine. The model of DNA structure formulated in 1953 explains these constant base ratios intact DNA consists of two polydeoxynucleotide molecules ( strands ). Each base in one strand is linked to a complementary base in the other strand by H-bonds. Adenine is complementary to thymine, and guanine is complementary to cytosine. One purine base and one pyrimidine base are thus involved in each base pair. [Pg.84]


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See also in sourсe #XX -- [ Pg.106 ]

See also in sourсe #XX -- [ Pg.106 ]




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