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Pyrimethamine antimalarial activity, resistance

Of interest is a recently described yeast-based, nutrient-dependent viability screen for inhibitors of protozoal dihydrofolate reductase (DHFR) [43,44], Antiprotozoal activity of DHFR inhibitors is well known, and DHFR- yeast complemented with the DHFR gene derived from the malaria parasite P. falciparum have been used to characterize the molecular pharmacology of resistance to the antimalarial DHFR inhibitors pyrimethamine and cycloguanil [45,46], The subsequent development of a screen was based on the demonstration that the protozoal... [Pg.331]

Pyrimethamine is a folic acid antagonist that for many years has been used as an antimalarial drug [193-195], specially for chloroquine-resistant P. falciparum. Due to its synergistic activity, pyrimethamine also has been used, in combination with sulfadiazine or dapsone for the treatment or prophylaxis of cerebral toxoplasmosis or PCP in patients with AIDS [196]. [Pg.366]

See other pages where Pyrimethamine antimalarial activity, resistance is mentioned: [Pg.615]    [Pg.87]    [Pg.141]    [Pg.133]    [Pg.782]    [Pg.678]    [Pg.260]    [Pg.273]    [Pg.275]    [Pg.515]    [Pg.587]    [Pg.158]    [Pg.184]    [Pg.286]    [Pg.758]    [Pg.243]    [Pg.258]    [Pg.284]    [Pg.40]    [Pg.323]   
See also in sourсe #XX -- [ Pg.40 ]



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Activation resistivity

Antimalarial

Pyrimethamine

Resistance active

Resistance, antimalarials

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