Pyridyl sulphoxides

Recently, it has been reported that methyl 2-pyridyl sulphoxides (10) and related pyridyl derivatives (11) (see Schepie 25) are good phase transfer catalysts for SN2 reactions of various primary or secondary alkyl halides in a two-phase reaction system and for the alkylation of phenylacetonitrile or phenylacetone with alkyl halides in liquid-liquid two-... 

The synthesis of the 3- and 4- pyridyl Grignard reagents (120) and (121) has been achieved by reaction of the corresponding phenyl pyridyl sulphoxide with phenyl magnesium bromide (Scheme 34). The pyridyl Grignards were trapped with aldehydes and ketones, and the... 

When the starting material is 7-hthio-3-(2-pyridyl)-triazolopyridine 71b (Scheme 14), the corresponding alcohol 73 or sulphoxide 75 are in... 

Electron Diffraction.—Among completed electron-diffraction studies are ethyl methyl sulphide, chloromethyl methyl sulphide, methyl phenyl sulphide, di-(2-pyridyl) sulphide, sulphones, sulphoxides and sulphones, and trifluoro-methanesulphonyl chloride. A number of precise analyses of gas-phase conformational equilibria have emerged. Methyl ethyl sulphide shows a preference for the gauche conformation rather than for the trans form. ... 

Useful products are also obtained by oxidizing alkyl and aryl pyridyl sulphides. With hydrogen peroxide, 2-methylthiopyridine and 6-methyl-thionicotinamide give the sulphoxides, and perbenzoic acid produces the sulphoxide from 2-benzylthiopyridine <. Hydrolysis of the dibromide from 2-pyridyl sulphide gives the sulphoxide" . More commonly the oxidation of... 

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