Pyridyl-porphyrin binding

Pyridyl-Porphyrin Binding to Zinc, Ruthenium and Rhodium Porphyrins... 

The anthraquinone derivative (2) represents the first example from 1997, with numerous others following in rapid succession, including the dibenzo-phenanthroline derivatives and tri-substituted acridines (3), which were reported to inhibit telomerase action in tumour cell lines with IC50 values of up to 28 and 60 nM, respectively. The tri-substituted acridines (3) were developed from the simple acridine (4) on the basis of structure-based design principles to maximise the quadruplex binding affinity. Thus, inhibition of telomerase by these compounds appears to be correlated to selective stabilisation of the human DNA quadruplex structure. Tetra-(A-methyl-4-pyridyl)-porphyrins... 

Extended versions of ditopic pyridyl porphyrins [95], tritopic and hex-atopic pyridyl-triporphyrins [96] bind into the cavities of hexameric porphyrin wheels. Very high binding constants in the range of 10 to 10 M e.g., in 38 (Fig. 30b) are reported for these encapsulated host-guest systems by Gossauer as is expected for an additive effect of the individual zinc-pyridine... 

The covalently linked bis-Zn(II) bis-porphyrins used by Rempel and coworkers - as platforms for two-point attachment of 5,15-bis(3-pyridyl)porphyrin 64, leading to parallel arrangements of porphyrins, were also used for two-point coordination of 5,10-bis(4-pyridyl)porphyrin 58 or 5,10-bis(3-pyridyl)porphyrin 63, that is, porphyrins in which the pyridyl arms are in cw-relative orientations (Figure 41). In the case of 58, a binding constant of 2.4 X lO mol" L was observed for the assembly 80,... 

Pd(II) and Pt(II) bisphosphine complex as auxiliaries.-- Because of the greater Pd-N, Pt-N bond strengths, the assemblies are found to be stable in a wide concentration range from 10 to at least 10 M. The Re(l) ion is also useful as the comer element for these porphyrin assemblies. The tetraporphyrin assembly obtained from Re(CO)5Cl and bis(pyridyl)porphyrin strongly binds tetrapyridylporphyrin to form pentaporphyrin assembly 184 with an association constant of 4 x 10 M" The complete substitution of... 

Naue JA, Toma SH, Bonacin JA, Araki K, Toma HE (2009) Probing the binding of tetraplatinum(pyridyl)porphyrin complexes to DNA by means of surface plasmon resonance. J Inorg Biochem 103(2) 182-189... 

Resonance Raman spectra were used to analyse distortions of the porphyrin substrate in enzyme and antibody catalysed ferrochelation reactions. SERS data were used to follow the metallation of 5,10,15,20-tetrakis(l-methyl-4-pyridyl)porphyrin in silver colloids.The resonance Raman spectrum of mesoporphyrin IX bound to ferrochelatase gave evidence of porphyrin distortion due to the binding. ... 

Fullerenes are spontaneously attracted to porphyrins and metalloporphyrins. The palladium-linked m-pyridyl dimer (shown in Figure 42) has a high binding constant in solution. Addition of C60 or C70 to solutions of these palladium-linked bis-porphyrins gave complexes that were chromatographically distinct from their individual components. This indication of tight binding was also seen in MALDI mass spectra.517... 

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