3- Pyridyl isocyanide

Di-2-pyridyl sulphite (343) (from 2-pyridone and thionyl chloride in the presence of triethylamine) transforms primary aliphatic and aromatic amines RNH2 into N-sulphinylamines RN=S=0 and it dehydrates amides ArCONH2 to aryl cyanides, aldehyde oximes RCH=NOH (R = Cxlf 7. 4-MeOCgH4 or PhCH=CH) to the cyanides RCN and A-alkyl- and TV-ary Iformamides RNHCHO to isocyanides RNC. Aliphatic and aromatic... 

A three-component one-pot condensation of 2-aminomethylpyridines 446, aldehydes, and isocyanides afforded 3-substituted 4-aminopyrido[l,2-fl] pyrazinium salts 447 (05OL2517) and not 4-(2-pyridyl)imidazols 448, as was stated earlier (05OL39). 

Bis[iV,iV -di(2-pyridyl)-imidazol-2-ylidene]aurate(I) tetrafluoroborates, preparation, 2, 292-293 Bis[iV,iV -di(2-pyridyl-methyl)-imidazol-2-ylidene]aurate(I) tetrafluoroborates, preparation, 2, 292-293 Bis(diselenolate) complexes, dinuclear iron compounds, 6, 242 Bis(dithiolene) compounds, in tungsten carbonyl and isocyanide complexes, 5, 644 Bis(enolato) complexes, with bis-Cp Ti(IV), 4, 589 Bis(enones), in reductive cyclizations, 10, 502 Bis(ethanethiolato) complexes, with bis-Cp Ti(IV), 4, 601 Bis(ethene)iridium complexes, preparation, 7, 328-329 -Bis(fluorenyl)zirconocene dichlorides, preparation,... 

Another novel multi-component reaction involving the synthesis of 4//-pyrido[ 1,2-ajpyrimidines 52, a motif found in many bioactive molecules, was reported by Adib et al. <07T11135 07TL4195>. The reaction involves the formation of a reactive 1 1 zwitterionic intermediate resulting from the addition of isocyanides 53 to dialkyl acetylenedicarboxylates 54 followed by trapping with A-(2-pyridyl)amidcs 55. 

The complex (OC)4Cr(p-C=NR)(p-dppm)Pt(PPh3), where R = CH2S02-/)-tolyl, gives an IR band from vC=N of the bridging isocyanide at 1667 cm-1.212 Resonance Raman data were reported for Mo(CO)4L, where L = 2,3-di(2-pridyl)-quinoxaline (dpq) or 5-methyl-2,3-di(2-pyridyl)-quinoxaline (5mdpq), for oxidised and reduced species. The latter showed bands from dpq-, 5mdpq- respectively.213... 

The product is soluble in water, but is only sparingly soluble in chloroform and methylene chloride. It can be solubilized in halogenated solvents by the addition of small amounts (ca. 5 % by volume) of MeOH, EtOH, MeCN, or THF. Otherwise, the ancillary ligands are assumed to be H20 or MeOH, depending on the sample s history. These coordinated water/methanol ligands are easily substituted over the course of several hours at room temperature. A variety of pyridyl ligands,10 isocyanides,18 and more complex ligands have been installed.16,17... 

Di-2-pyridyl sulfite 1660 is presented as a useful reagent for the preparation of isocyanides under mild conditions [1230], Yields given in the table therein are good (70-82% for test alkyl, benzylic, and aryl isocyanides). The reagent (prepared from 2-hydroxypyridine 1659 and thionyl chloride) is rather unstable, but can be stored in a refrigerator for a week without decomposition , according to the authors. 

Ruthenium. NMR isotropic shifts have been observed for low-spin Ru isocyanide porphyrin complexes. NMR data have also been reported for [Ru2(acac)4 3,6-(2-pyridyl)2-1,2,4,5-tetrazine ]. ... 

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