Pyridoxol phosphate biosynthesis

Figure 25-21 Proposed pathways for biosynthesis of thiamin phosphate and pyridoxol phosphate.

Cane, D.E. et al (1999) Biosynthesis of vitamin B6 enzymatic conversion of l-deoxy-D-xylulose-5-phosphate to pyridoxol phosphate. /. Am. Chem. Soc., 121 (33), mi-iin. 

Sprenger, G.A. et al.. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol, Proc. Natl. Acad Sci. USA 94, 12857, 1997. Lange, B.M. et al., A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway, Proc. Natl. Acad Sci. USA 95, 2100, 1998. Lois, L.M. et al., Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1- deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis, Proc. Natl. Acad. Sci. USA 95, 2105, 1998. 

LM Lois, N Campos, SR Putra, K Danielsen, M Rohmer, A Boronat. Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-l-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. Proc Natl Acad Sci (USA) 95 2105-2110, 1998. 

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