Pyridone pyridoxal 5 -phosphate

The synthesis pathway of quinolizidine alkaloids is based on lysine conversion by enzymatic activity to cadaverine in exactly the same way as in the case of piperidine alkaloids. Certainly, in the relatively rich literature which attempts to explain quinolizidine alkaloid synthesis °, there are different experimental variants of this conversion. According to new experimental data, the conversion is achieved by coenzyme PLP (pyridoxal phosphate) activity, when the lysine is CO2 reduced. From cadeverine, via the activity of the diamine oxidase, Schiff base formation and four minor reactions (Aldol-type reaction, hydrolysis of imine to aldehyde/amine, oxidative reaction and again Schiff base formation), the pathway is divided into two directions. The subway synthesizes (—)-lupinine by two reductive steps, and the main synthesis stream goes via the Schiff base formation and coupling to the compound substrate, from which again the synthetic pathway divides to form (+)-lupanine synthesis and (—)-sparteine synthesis. From (—)-sparteine, the route by conversion to (+)-cytisine synthesis is open (Figure 51). Cytisine is an alkaloid with the pyridone nucleus. 

Pyridocarbazole alkaloids, 21 Pyridon, 109, 127 Pyridone, 142, 143 Pyridon quinolizidine alkaloids, 141 Pyridostigmine, 158 Pyridoxal phosphate, 116 Pyriferines A-C, 65-67 Pyrolidines, 8... 

Pyridone Pyridone-2 2(1 H)-Pyridone a-Pyridone. See 1-Hydroxy-2-pyridine Pyridoxaldehyde phosphate Pyridoxal, 5-(dihydrogen phosphate) Pyridoxal monophosphate Pyridoxal P Pyridoxal phosphate. See Pyridoxal 5-phosphate Pyridoxal 5-phosphate CAS 54-47-7 41468-25-1 (monohydrate) EINECS/ELINCS 200-208-3 Synonyms Codecarboxylase 3-Hydroxy-2-methyl-5-[(phosphonooxy) methyl]-4-pyridinecarboxaldehyde Phosphopyridoxal Phosphoridoxal coenzyme 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy) methyl]-Pyridoxaldehyde phosphate Pyridoxal, 5-(dihydrogen phosphate) Pyridoxal monophosphate Pyridoxal P Pyridoxal phosphate Pyridoxyl phosphate Classification Organic compd. 

Abbreviations TPP, thiamin pyrophosphate MNA, A/ -methyInicotinamide 2-Pyr, A/ -methyl-2-pyridone-5-carboxamide PLP, pyridoxal-5 -phosphate LC, liquid chromatography UV, ultraviolet detection FL, fluorescence detection CPB, competitive proteinbinding assay. 

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