Pyrido pyrimidines applications

Applications of MCR-Derived Heterocycles in Drug Discovery Table 6 Antibacterial activities of select pyrazolo-pyrido-pyrimidine-diones... 

Application of aluminum trichloride in chlorobenzene341 for the condensation with tetra-0-acetyl-/ -D-ribofuranose gives the 8-(2,3,5-tri-0-acctyl-j6-D-ribofuranosyl)pyrido[2,3-tf]-pyrimidine-2,4(l//,3//)-dione (17).83... 

Biological applications included SAR of 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines <97JMC3915>, 4-(phenylamino)-17/-pyrazolo[3,4-d]py rimidines<97JMC3601 >,... 

Monocyclic and Bicyclic aromatic heterocycles such as imidazoles, thiazoles, thiadiazoles, oxazoles, oxadiazoles quinazolines, indoles, benzimidazoles, purines pyrido[43-d]pyri-midines, thiazolo[5,4-d]pyrimidines, thiazolo[4,5-d]pyrimidines, oxazolo[5,4-d]pyrimi-dines and thieno[2,3-d]pyrimidines are renowned pharmacophores in drug discovery. These special structures are well explained and exemplified in chemical compound libraries. In this chapter, several types of thiazole based heterocyclic scaffolds such as mono-cyclic or bicyclic systems synthesis and their biological activities studies are presented, which are not frequently present in books and reviews. We mention the first importance of synthetic route of various thiazole based compounds and their applications in medicinal chemistry in this chapter. 

Molina, P., Eresneda, P.M., and Delgado, S. (2003) Carbodiimide-mediated preparation of the tricyclic pyrido[3, 2 4,5]pyrrolo[l,2-c] pyrimidine ring system and its application to the synthesis of the potent antitumoral marine alkaloid variolin B and analog. J. Org. Chem., 68, 489-499. 

Introduction. The principal synthetic application of 3,4-dihydro-2//-pyrido[ 1,2-a]pyrimidin-2-one (1) is an acid scavenger it is an example of a proton sponge (see 1,8-Bis(dimethylamino)naphthalene). The reagent has been used in... 

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