Pyrido acridin-8-ones

Heterocyclic compounds which have, as a common structural feature, a tetracyclic pyrido[2,3,4-k/ acridine system often offer striking biological activities such as antitumor activities. Specifically, a facile synthesis of ascididemine (70) was achieved by high-pressure IEDAR of 6H-4-bromopyrido[2,3,4-/d]acridin-6-one (69) with propanal dimethylhydrazone... 

In an attempted reaction toward a pyrido[2,3,4-/c/]acridine, Gellerman et al. (92TL5577) isolated a pyrido[2,3-a]acridine 11 from an acid-catalyzed reaction between l-amino-4-methylacridin-9(10//)one 10 and acetylace-tone (Scheme 4). 

CAN-mediated dehydrogenation leads to a variety of aromatic coii5)ounds such as quinoline, pyridazine, thiadiazole, pyrido[4,3,2-kl]acridin-4-one, azobenzene, and tetrazole derivatives. 

H-pyrido[2,3,4-W acridin-4-ol 13,14-dihydro-12H-pyrido[4,3,2-mn]pynolo Eudistoma [3,2,1 -de][1,4]thiazino[3,2-b]acridin-13-one... 

Pascual-Alfonso, E., Avendano, C., and Menendez, J.C. (2003) Efficient synthesis of the pyrido[2,3,4-kl]acridin-4-one system common to several cytotoxic marine alkaloids. Tetrahedron Lett., 44, 6003-6005. 

A domino reaction initiated by an Au(I)-catalysed 6-endo-dig cycloisomerization gives pentacyclic pyrido[4,3,2-m ]acridin-8-ones A-propargylaminoquinones (Scheme 118). ... 

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