Pyridinyl

Chemical Name 2-[(4-chlorophenyl)-2-pyridinyl-methoxy], N,N-dimethylethanamine maleate... 

Chemical Name N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-1 H-indene-2-ethanamine maleate Common Name —... 

Chemical Name N,N-dimethyl-N -2-pyridinyl-N -(2-thienylmethyl)-1,2-ethanediamine hydrochloride... 

However, addition of (+ )-(7 )-l-methyl-4-(mcthylsulfinyl)benzene, to aldehydes and ketones proceeds with low stereoselectivity. An improvement of the 3-syn diaslereoselectivity was found with the zinc reagent obtained by transmetalation of the lithiated sulfoxide with anhydrous zinc chloride38. An improvement of the stereoselectivity was also attained by exchange of the 4-methylphenyl substituent for a 2-methoxyphenyl or 2-pyridinyl substituent. Thus, the introduction of an additional complexing site into the aromatic part of the sulfoxide reagent enhances the stereoselectivity35. 

Similarly, Kappe and Walla showed that (2-pyridinyl)zinc chloride can be quickly cross-coupled with electron-deficient aryl chlorides using Pd2(dba)3/ t-Bu3P.HBp4 as a precatalyst in THF at 175 °C for 10 min (Scheme 2) [21]. hi a reverse approach, 4-chloropyridine rapidly reacted with (4-methoxyphenyl) zinc chloride (Scheme 2). 

CN carbonic acid ethyl l [[2-methyI-3-[(2-pyridinyl)aminocarbonyl]-2//-l,2-benzoihiazin-4-yI]oxylethyI ester 5,5 -dioxide... 

CN Af-[(4-chlorophenyl)methyl]-A ,A -dimethyl-A-2-pyridinyl-l,2-ethanediamine monohydrochloride... 

CN N-[(5-chloro-2-thienyl)methyl]-A/ ,V-dimethyl-N-2-pyridinyl-l,2-ethanediamine... 

CN l-[3-[( 1 -Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]- l//-indol-2-yl]-carbonyljpiperazine monomethanesulfonate... 

CN 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-l//-benzimidazole... 

CN 6-Chloro-4-hydroxy-2-methyl-A-2-pyridinyl-2//-thieno[2,3-e]-l,2-thiazine-3-carboxamide 1,1-dioxide... 

CN ( )-5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyI]-2,4-thiazolidinedione hydrochloride... 

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