Pyridine-2-carboxylic acid amide

R te Constants for Reduction of IsOnicotinamide (4-Pyridine Carboxylic Acid Amide) Complexes by [Cr(H20)6] ... 

Nicotinic acid (3-pyridine carboxylic acid or niacin) nicotinamide (nicotinic acid amide), niacinamide, 3-pyridine-carboxylic acid amide Thiamines, hydroxy-ethylthiamine... 

TABLE XXVn. l-Methyl-l,6-dihydropyrazolo[3,4-c]pyridin-7-ones Prepared by Cyclization of Vicinal 4-(Alkyn- l-yl)pyrazole-5-carboxylic Acid Amides [90IZV2089]. 

The involvement of zinc in nicotinamide-based hydride-transfer reactions has led to numerous studies of Group IIB complexes of pyridine carboxylic acid derivatives. Cadmium complexes of 2-pyridinecarboxylic acid, 5 3-pyridinecarboxylic add497 and 3-pyridinecarboxamide498 have been reported. The crystal structure of [Cd(HC02)2L2(H20)2] (L = 3-pyridinecarboxamide) has also been described the metal is in an octahedral environment in which the amide acts as a monodentate N donor.498... 

Dehydration of pyridine-3-carboxylic acid amide (Nicotinamide) Dehydration of nicotinamide was carried out at different temperatures using conditions similar to those employed for benzamide. The results are shown in Fig.4. The reaction followed zero order kinetics and rate of reaction is very comparable to that of dehydration of benzamide. The kinetic constants are given in Table 2. In contrast with benzamide dehydration of nicotinamide in the absence of catalyst was negligible. 

Fig. 7.4. Triftuoromethane-sulfonic acid an hydride/pyridine-mediated dehydration of primary carboxylic acid amides (A) to give the corresponding nitriles (B) with the reagents converting into pyridinium trifluormethanesulfonate pyrH F3C-S03 .

Preparation of 5-pyridine-3-yl-4-[2-(2-trifluoromethoxy-phenyl)-acetylammo]-lH-pyrazole-3-carboxylic acid amide... 

The preparation of Step 1 co-reagent, 4-amino-5-pyridine-3-yl-lH-pyrazol-3-carboxylic acid amide, (I), was provided by the author and illustrated in Eq. 2. 

In acid solution the carbinol might be reduced further. Pyridine carboxylic acids,2812-carboxythiazoles,282and 2-carboxyimidazoles263 and their amide derivatives have been reduced in this way. The yields of aldehydes in some of these reactions are given in Table I.283... 

PELONIN AMIDE PP-FACTOR PYRIDINE-3-CARBOXYLIC ACID AMIDE 3-PYRIDINECARBOXYD IC ACID AMIDE VI-NICOTYL VI-NICTYL VITAMIN B3 VITAMIN PP WITAMINA PP... 

The pyridine analogue is reported from pyridine-2-carboxylic acid amide. 

CeHeONz Pyridine-3-carboxylic acid amide (nicotinamide)... 

Benzenesulfonyl chloride pyridine Subst. carboxylic acid amides from carboxylic acids... 

Pyridine side chain carboxylic acid amides, alkylation of, 361... 

Dicyclohexylcarbodiimide/pyridine Nitriles from carboxylic acid amides... 

The name niacin is often used for two compounds, namely pyridine-3-carboxylic acid and pyridine-3-carboxylic acid amide. This confusion occurs because there is no consistency in the empirical nomenclature used in nutrition literature. Harris 1 lists niacin and niacinamide as the terms preferred in the United States, and nicotinic acid and nicotinic acid amide in the British literature. A convenient solution to the problem would be to use the term niacin to refer generically to the two compounds of nutritional significance as anti-pellagra factor and adopt the names nicotinic acid and nicotinamide to refer specifically to each. Nicotinamide has been adopted by the Commission for the Reform of Nomenclature in Biological Chemistry of the International Union of Pure and Applied Chemistry, and nicotinic acid is already in current use in most British, United States and other scientific literature in English. 

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