Pyridine benzo-fusion, effect

Even though data for a quantitative comparison are lacking, the effect of the position of benzo-fusion onto pyridazines is analogous to that with pyridines in producing the very poorly reactive 3-chloro-cinnoline (396) and highly reactive 1-chlorophthalazine (Table XV, lines 8 and 9). 

The monoazanaphthalenes provide a good illustration of the effect of benzo-fusion onto an azine and of the variation of the effect with the position of fusion. A benzo ring can be fused onto 2-chloro-pyridine at the 3,4- [leading to 1-ohloroisoquinoline (393 ], at the... 

Heteroatom Alkylation. Previous work (referred to in last year s Report) on the steric effect of benzo-fusion on the rates of quaternization of pyridine and thiazole... 

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