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Pyrene oxidations

Hemoglobin is another heme-containing protein, which has been shown to be active towards PAH, oxidation in presence of peroxide [420], This protein was also modified via PEG and methyl esterification to obtain a more hydrophobic protein with altered activity and substrate specificity. The modified protein had four times the catalytic efficiency than that of the unmodified protein for pyrene oxidation. Several PAHs were also oxidized including acenaphthene, anthracene, azulene, benzo(a)pyrene, fluoranthene, fluorene, and phenanthrene however, no reaction was observed with chrysene and biphenyl. Modification of hemoglobin with p-nitrophenol and p-aminophenol has also been reported [425], The modification was reported to enhance the substrate affinity up to 30 times. Additionally, the solvent concentration at which the enzyme showed maximum activity was also higher. Both the effects were attributed to the increase in hydrophobicity of the active site. [Pg.197]

Monooxygenase Assays. Incubation media contained the following (final concentrations) 0.05M phosphate buffer, pH 7.A, glucose-6-phosphate (G-6-P, 2.3 mM), G-6-P dehydrogenase (3 units), NADP (0.23 mM), and KC1 (2.8 mM), and various tissue preparations. Substrates were added in small volumes (25 yl or less) of MeOH. Samples (1.1 ml) were shaken in a thermostated (usually at 22°C) water bath and reactions terminated by enzyme denaturation. Specific analytical procedures for aldrin epoxi-dation (13), 1 CH30-p-nitroanisole 0-demethylation (1A), and 3H-benzo(a)pyrene oxidation (15) have been described. [Pg.262]

Pyrene oxidation reaction in 60 mM phosphate buffer pH 6.1, 30° C. Pyrene concentration 35 pM [58]... [Pg.340]

Benzo[a]pyrene in soot was the culprit for a large number of skin cancers in young boys who cleaned chimneys in the 1700s. The body transforms this compound to 4,5-benzo[a]pyrene oxide, a reactive epoxide that forms a covalent bond with DNA. [Pg.737]

Figure 8 Schematic representation of binding interactions of aiene oxides at the H site of GST A, (4R,5S -benzo[a]pyrene oxide B, (5S,6R)-benzo[a]anthracene oxide C, (4R,5S)-pyiene oxide D, (7S)-styrene oxide, and E, (7R)-styrene oxide. (Taken from Dostal et al., 1986.)... Figure 8 Schematic representation of binding interactions of aiene oxides at the H site of GST A, (4R,5S -benzo[a]pyrene oxide B, (5S,6R)-benzo[a]anthracene oxide C, (4R,5S)-pyiene oxide D, (7S)-styrene oxide, and E, (7R)-styrene oxide. (Taken from Dostal et al., 1986.)...
Figure 28 Glutathione conjugation reactions of aromatic and OC, P-unsatu-rated carbonyl compounds, benzo[a]pyrene oxide, and ethacrynic acid, respectively. Figure 28 Glutathione conjugation reactions of aromatic and OC, P-unsatu-rated carbonyl compounds, benzo[a]pyrene oxide, and ethacrynic acid, respectively.
K. Inoue, and E.M.J. Gillam (2001). Specificity of I7p-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P450 IBl variants substituted at residues 48, 119, and 432. Xenobiotica 31, 163—176. [Pg.469]

Scheme S.IO Multistep pyrene oxidations catalyzed by CYP1A2. Scheme S.IO Multistep pyrene oxidations catalyzed by CYP1A2.
Ex-cdl oxidation carried out solid to solid. Also pyrene oxidized similajiy. [Pg.320]


See other pages where Pyrene oxidations is mentioned: [Pg.55]    [Pg.311]    [Pg.313]    [Pg.483]    [Pg.112]    [Pg.65]    [Pg.737]    [Pg.17]    [Pg.141]    [Pg.461]    [Pg.461]    [Pg.345]    [Pg.729]    [Pg.729]    [Pg.183]    [Pg.53]    [Pg.366]    [Pg.514]    [Pg.514]   
See also in sourсe #XX -- [ Pg.197 ]

See also in sourсe #XX -- [ Pg.215 ]




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4,5-Benzo pyrene oxide

Benzo pyrene 4,5-oxide, conjugation

Benzo pyrene oxidation

Benzo pyrene oxides from

Epoxide hydrolase benzo pyrene-4,5-oxide

Glutathione transferase benzo pyrene-4,5-oxide

Pyrene oxidation naphthalene oxide

Pyrene-4,5-oxide

Pyrene-4,5-oxide

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