Pyrene Cunninghamella

Cerniglia CE, DT Gibson (1979) Oxidation of benzo[a]pyrene by the filamentous fungus Cunninghamella elegans. J Biol Chem 254 12174-12180. 

Cerniglia, C. E., Mahaffey, W. Gibson, D. T. (1980c). Fungal oxidation of benzo(a)pyrene formation of (-)-rranr-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene by Cunninghamella elegans. Biochemistry and Biophysics Research Communications, 94, 226-32. 

Fig. 8.4. Fungal metabolism of pyrene (after CernigUa et al., 1986 Cerniglia Sutherland, 2005). A. niger, Aspergillus niger, C. elegans, Cunninghamella elegans, I. lacteus, Irpex lacteus P. chrysosporium, Phanerochaete chrysosporium P. ostreatus, Pleurotus ostreatus.

Fig. 8.5. Fungal metabolism of benzo[a]pyrene (after Cerniglia Gibson, 1979 Cerniglia Sutherland, 2006). C. elegans, Cunninghamella elegans F. solani, Fusarium solani P. chrysosporium, Phanerochaete chrysosporium P. pulmonarius, Pleurotus pulmonarius S. coronilla Stropharia coronilla.

For example, Cunninghamella elegans oxidizes benzo[a]pyrene to its 7,8-oxide, hydrates the 7,8-oxide to the 7,8-dihydrodiol, and metabolizes this as well as the 9,10-dihydrodiol to diol epoxides " with stereochemical consequences quite similar to those observed for liver microsomes from the 3-methyl-cholanthrene-treated... 

Cunninghamella elegans l-Nitropyrene-6-a-D-glucopyranoside Mycobacterium sp. PYR-1 l-Nitropyrene-8-a-D-glucopyranoside 1 -Nitropyrene c/5-4,5-dihydrodiol 1-Nitropyrene c/5-9,10-dihydrodiol 1-Aminopyrene 3-Nitrofluoranthene-8-sulfate 3-Nitrofluoranthene-9-sulfate 6-Nitrobenzo[a]pyrene- 1-a -D-glucopyranoside 6-Nitrobenzo[flf]pyrene-3-a -D-glucopyranoside... 

---