Cunninghamella elegans

Leucomycines Ai and A3 Magnamydns A and B Middamydn Corresponding 4"-0- deisovaleryl derivatives Cunninghamella elegans and other fungi Streptomyces sp. 

Pothuluri JV, JP Freeman, FE Evans, TB Moorman, CE Cerniglia (1993) Metabolism of alachlor by the fungus Cunninghamella elegans. J Agric Food Chem 41 483-488. 

FIGURE 8.19 Biotransformation of 7-methylbenz[a]anthracene by Cunninghamella elegans. 

FIGURE 8.20 Alternative pathways for the biotransformation of fluoranthene by Cunninghamella elegans. 

Cerniglia CE, DT Gibson (1979) Oxidation of benzo[a]pyrene by the filamentous fungus Cunninghamella elegans. J Biol Chem 254 12174-12180. 

Cerniglia CE, KL Lambert, DW Mille, JP Freeman (1984b) Transformation of 1- and 2-methylnaphthalene by Cunninghamella elegans. Appl Environ Microbiol 47 111-118. 

Cerniglia CE, PP Fu, SK Yang (1982c). Metabolism of 7-methylbenz[a]anthracene and 7-hydroxymethylbenz [a]anthracene by Cunninghamella elegans. Appl. Environ. Microbiol. 44 682-689. 

Cunninghamella elegans metabolized 1-fluoronaphthalene to a number of products whose synthesis was clearly initiated by the formation of epoxides and trani-dihydrodiols (Figure 9.28) (Cerniglia et al. 1984). This illustrates the apparent indifference of the monooxygenase to the presence of fluorine atoms. 

FIGURE 9.28 Transformation of 1-fluoronaphthalene by Cunninghamella elegans. (From Neilson, A.H. and Allard, A.-S., The Handbook of Environmental Chemistry, Vol. 3R, Springer Verlag, 2002, pp. 1-74. With permission.)... 

Moody, J.D., Freeman, J.P. and Cerniglia, C.E. (1999) Biotransformation of doxepin by Cunninghamella elegans. Drug Metabolism and Disposition The Biological Fate of Chemicals, 27, 1157-1164. 

Sutherland, J.B., Freeman, J.P, Heinze, T.M. et al. (2001) Oxidation of phenothiazine and phenoxazine by Cunninghamella elegans. Xenobiotica The Fate of Foreign Compounds in Biological Systems, 31, 799-809. 

A cytochrome P450-based oxidation of DBT was reported by Cunninghamella elegans ATCC 36112 [102], This resulted in formation of DBT sulfoxide and sulfone however, the organism did not have any enzymes to further oxidize the sulfone. 

Scheme 23. O-Dealkylation reactions of apoiphines by Cunninghamella elegans ATCC 9245.

Phenacetin Analgesic NH-COCH3 9 O-CHsCHg 0-Dealkylation, N-hydro-xylation and arene oxide formation Glutathione conjugates 0-Dealkylation (Cunninghamella elegans) [97]... 

N-demethylation (Gliocladium roseum, Cunninghamella elegans, C. blakesleeana)... 

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