Pyrazolo thiazepines

The synthesis of a number of new pyrazolo[3,2-c][2, IJbenzothiazepines 2-phenylpyridazino[4,5-6][l,5]thiazepines is reported <96JHC151, 96JHC583>. 

Hydroxy-l-phenyl-lH- [Pg.697]

Tricyclic systems as compounds of potential pharmacological interest prepared by conventional cyclisation procedures include thienoanellated [l,4]benzoxazepines <94JHC1053>, pyrido[l,4] and [l,5]benzoxazepines and thiazepines <94JMCS19>, and IH- and 2H-pyrazolo[3,4-c][2,l]benzothiazepines <94JHC93>. A number of... 

In a catalyst-free, aqueous-mediated MCR facilitated by sonication, isat-ins 200, 5-amino-3-methylpyrazole 201 and a-mercaptoacetic acids 202 reacted to form spiro(indole-3,4 -pyrazolo[3,4-e][l,4]thiazepines) 203 in high yield. Replacement of the isatin with acenaphthylene-1,2-dione or N-substitued piperidin-4-ones gave the corresponding spiro(pyrazolo-1,4-thiazepines) (13RA18992). 

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