Pyrazinethiol

This section is mainly about tautomeric pyrazinethiones but the meagre available information on nontautomeric pyrazinethiones and pyrazinethiols is also included. 

Most tautomeric pyrazinethiones have been made by primary synthesis (see Chapters 1 and 2), thiolysis of halogenopyrazines (see Section 4.2.4), or thiation of tautomeric pyrazinones (see Section 5.1.2.1) a few nontautomeric pyrazinethiones by primary synthesis (see Chapters 1 and 2) or thiation of nontautomeric pyrazinones (see Section 5.4.2) and nearly all extranuclear pyrazinethiols by thiolysis of extranuclear halogenopyrazines (see Section 4.4). Other routes to such pyrazinethiones and pyrazinethiols are illustrated in the following examples ... 

The formation of such pyrazines by primary synthesis has been covered in Chapters 1 and 2 the meagre literature on their formation by oxidation of pyrazinethiones or pyrazinethiols is mentioned in Section 6.1.2. 

This is an improvement of an earlier procedure in which benzenethiol was used as the precursor. The method gives high yields, but several steps are involved and the pyrazinethiol must be prepared separately-... 

Typical procedure. t-Butoxycarbonylated pyrazinols 57 [38] To a solution of a pyra-zinol (10 mmol) or pyrazinethiol (10 mmol) in dioxane (50 mL), sodium hydride (480 mg, 10 mg atom) was added and the reaction mixture was stirred at room... 

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