Pyrazinecarbohydrazides from pyrazinecarboxylic esters

PREPARATION. Pyrazinecarbohydrazides have been made by primary synthesis (see Chapters 1 and 2), from pyrazinecarboxylic esters (see Section 8.2.2), from pyrazinecarbonyl halides (see Section 8.2.3), and by transamination of pyrazinecarboxamides (see Section 8.4.2). 

Methyl 2-pyrazinecarboxylate (90) gave A -methyl-2-pyrazinecarbohydrazide (89) without any of the. V-m ethyl isomer (91) [MeHNNH2, EtOH, reflux, 12 h 81% the isomer (91) can be made from 2-pyrazinecarbonyl chloride see Section 8.3.2] analogous esters behaved similarly to give, for example, 3-amino-/V -methyl-2-pyrazinecarbohydrazide (71%).1265... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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