Pyrazinecarbonyl halides

Several routes to such derivatives have been covered already by primary synthesis (Chapters 1 and 2), from halogenopyrazines by displacement (Section 4.2.9), from pyrazine carboxylic acids (Section 8.1.2), from pyrazinecarboxylic esters (Section 8.2.2), and from pyrazinecarbonyl halides (Section 8.3.2). The remaining methods of preparation are illustrated in the following examples ... 

Pyrazinecarbonyl azides have been made from pyrazinecarbonyl halides (see Section 8.3.2) but more usually from pyrazinecarbohydrazides with nitrous acid as exemplified here. 

Several major routes to pyrazine ketones have been covered already by primary synthesis in Chapters 1 and 2, by oxidation of aralkylpyrazines in Section 3.2.4.1, by oxidation of secondary hydroxyalkylpyrazines in Section 5.2.2, from pyrazinecarboxylic esters by the Claisen reaction in Section 8.2.2, from pyrazinecarbonyl halides (using several methods) in Section 8.3.2, and frompyrazinecarbonitriles with a Grignard (or similar reagent) in Section 8.6.2. 

Reactions of Pyrazinecarbonyl Halides Pyrazinecarboxamides, Pyrazinecarboxamidines, and Related Derivatives... 

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