Pyrazine ketones from pyrazinecarboxylic esters

Note Reactions of the mixed-Claisen type afford a convenient route from pyrazinecarboxylic esters to some pyrazine ketones. 

Several major routes to pyrazine ketones have been covered already by primary synthesis in Chapters 1 and 2, by oxidation of aralkylpyrazines in Section 3.2.4.1, by oxidation of secondary hydroxyalkylpyrazines in Section 5.2.2, from pyrazinecarboxylic esters by the Claisen reaction in Section 8.2.2, from pyrazinecarbonyl halides (using several methods) in Section 8.3.2, and frompyrazinecarbonitriles with a Grignard (or similar reagent) in Section 8.6.2. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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