Pyrazinamide Foods

Peloquin CA, Bulpitt AE, Jaresko GS, et al. Pharmacokinetics of pyrazinamide under fasting conditions, with food, and with antacids. Pharmacotherapy 1998 18 1205-1211. 

Mechanism of Action Pyrazinamide is especially useful because it is particularly active against the semi-dormant intracellular tubercle bacilli which are found to be not affected by other drugs. Thus, the combined pyrazinamide therapy has remarkably reduced the treatment regimen from 9 months to merely 6 months. The drug is least affected by the presence of food in the gastro-intestinal (Gl) tract, nor by the concurrent usage of Al-Mg-antacids. 

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